| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_04580 | ISM_05240 | ISM_04580 | ISM_05240 | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamideacetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.858 |
| ISM_04580 | ISM_05245 | ISM_04580 | ISM_05245 | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.777 |
| ISM_04580 | ISM_10915 | ISM_04580 | ISM_10915 | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.748 |
| ISM_04580 | ISM_11170 | ISM_04580 | ISM_11170 | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | acyl-CoA synthetase, putative; COG1042 Acyl-CoA synthetase (NDP forming). | 0.741 |
| ISM_04580 | ISM_14700 | ISM_04580 | ISM_14700 | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | 0.768 |
| ISM_04580 | leuA | ISM_04580 | ISM_02200 | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.883 |
| ISM_05240 | ISM_04580 | ISM_05240 | ISM_04580 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamideacetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.858 |
| ISM_05240 | ISM_05245 | ISM_05240 | ISM_05245 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamideacetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.996 |
| ISM_05240 | ISM_09180 | ISM_05240 | ISM_09180 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamideacetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.531 |
| ISM_05240 | ISM_10915 | ISM_05240 | ISM_10915 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamideacetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.743 |
| ISM_05240 | ISM_11165 | ISM_05240 | ISM_11165 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamideacetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | COG1960 Acyl-CoA dehydrogenases. | 0.465 |
| ISM_05240 | ISM_11170 | ISM_05240 | ISM_11170 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamideacetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | acyl-CoA synthetase, putative; COG1042 Acyl-CoA synthetase (NDP forming). | 0.743 |
| ISM_05240 | ISM_14700 | ISM_05240 | ISM_14700 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamideacetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | 0.659 |
| ISM_05240 | leuA | ISM_05240 | ISM_02200 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamideacetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.858 |
| ISM_05245 | ISM_04580 | ISM_05245 | ISM_04580 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 2-isopropylmalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.777 |
| ISM_05245 | ISM_05240 | ISM_05245 | ISM_05240 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamideacetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.996 |
| ISM_05245 | ISM_09180 | ISM_05245 | ISM_09180 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.554 |
| ISM_05245 | ISM_10915 | ISM_05245 | ISM_10915 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.554 |
| ISM_05245 | ISM_11165 | ISM_05245 | ISM_11165 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | COG1960 Acyl-CoA dehydrogenases. | 0.664 |
| ISM_05245 | ISM_11170 | ISM_05245 | ISM_11170 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | acyl-CoA synthetase, putative; COG1042 Acyl-CoA synthetase (NDP forming). | 0.773 |