| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00820 | ISM_11415 | Oxidoreductase, zinc-binding dehydrogenase family protein; COG1062 Zn-dependent alcohol dehydrogenases, class III. | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | 0.952 |
| ISM_02320 | ISM_11415 | Glutathione-dependent formaldehyde dehydrogenase; COG1062 Zn-dependent alcohol dehydrogenases, class III; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | 0.952 |
| ISM_03160 | ISM_03165 | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | 0.999 |
| ISM_03160 | ISM_11415 | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | 0.833 |
| ISM_03165 | ISM_03160 | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | 0.999 |
| ISM_03165 | ISM_11415 | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | 0.843 |
| ISM_03165 | ISM_11420 | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | Aldehyde dehydrogenase, putative; COG1012 NAD-dependent aldehyde dehydrogenases. | 0.416 |
| ISM_08310 | ISM_11415 | COG1012 NAD-dependent aldehyde dehydrogenases. | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | 0.974 |
| ISM_08310 | ISM_14700 | COG1012 NAD-dependent aldehyde dehydrogenases. | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | 0.535 |
| ISM_11415 | ISM_00820 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | Oxidoreductase, zinc-binding dehydrogenase family protein; COG1062 Zn-dependent alcohol dehydrogenases, class III. | 0.952 |
| ISM_11415 | ISM_02320 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | Glutathione-dependent formaldehyde dehydrogenase; COG1062 Zn-dependent alcohol dehydrogenases, class III; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. | 0.952 |
| ISM_11415 | ISM_03160 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | 0.833 |
| ISM_11415 | ISM_03165 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | 0.843 |
| ISM_11415 | ISM_08310 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | COG1012 NAD-dependent aldehyde dehydrogenases. | 0.974 |
| ISM_11415 | ISM_11420 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | Aldehyde dehydrogenase, putative; COG1012 NAD-dependent aldehyde dehydrogenases. | 0.975 |
| ISM_11415 | ISM_11425 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | Gamma-glutamylisopropylamide synthetase, putative; COG0174 Glutamine synthetase. | 0.945 |
| ISM_11415 | ISM_11430 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | Bacterial extracellular solute-binding protein, family 7 protein; COG4663 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component. | 0.863 |
| ISM_11415 | ISM_11440 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | TRAP-T family transporter, DctQ (4TMs) subunit; COG4665 TRAP-type mannitol/chloroaromatic compound transport system, small permease component. | 0.845 |
| ISM_11415 | ISM_14700 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | 0.837 |
| ISM_11420 | ISM_03165 | Aldehyde dehydrogenase, putative; COG1012 NAD-dependent aldehyde dehydrogenases. | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | 0.416 |