| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_06100 | ISM_06105 | ISM_06100 | ISM_06105 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | 0.999 |
| ISM_06100 | ISM_11415 | ISM_06100 | ISM_11415 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | 0.778 |
| ISM_06100 | ISM_11420 | ISM_06100 | ISM_11420 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Aldehyde dehydrogenase, putative; COG1012 NAD-dependent aldehyde dehydrogenases. | 0.699 |
| ISM_06100 | ISM_11425 | ISM_06100 | ISM_11425 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Gamma-glutamylisopropylamide synthetase, putative; COG0174 Glutamine synthetase. | 0.933 |
| ISM_06100 | ISM_12965 | ISM_06100 | ISM_12965 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.978 |
| ISM_06100 | carA | ISM_06100 | ISM_09911 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | 0.910 |
| ISM_06100 | carB | ISM_06100 | ISM_01525 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | 0.954 |
| ISM_06100 | glmS | ISM_06100 | ISM_14195 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | D-fructose-6-phosphate amidotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.945 |
| ISM_06100 | purF | ISM_06100 | ISM_15845 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.913 |
| ISM_06105 | ISM_06100 | ISM_06105 | ISM_06100 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.999 |
| ISM_06105 | ISM_11425 | ISM_06105 | ISM_11425 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | Gamma-glutamylisopropylamide synthetase, putative; COG0174 Glutamine synthetase. | 0.863 |
| ISM_06105 | ISM_12965 | ISM_06105 | ISM_12965 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.875 |
| ISM_06105 | carA | ISM_06105 | ISM_09911 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. | 0.853 |
| ISM_06105 | carB | ISM_06105 | ISM_01525 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family. | 0.867 |
| ISM_06105 | glmS | ISM_06105 | ISM_14195 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | D-fructose-6-phosphate amidotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.867 |
| ISM_06105 | purF | ISM_06105 | ISM_15845 | COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.852 |
| ISM_11415 | ISM_06100 | ISM_11415 | ISM_06100 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.778 |
| ISM_11415 | ISM_11420 | ISM_11415 | ISM_11420 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | Aldehyde dehydrogenase, putative; COG1012 NAD-dependent aldehyde dehydrogenases. | 0.973 |
| ISM_11415 | ISM_11425 | ISM_11415 | ISM_11425 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | Gamma-glutamylisopropylamide synthetase, putative; COG0174 Glutamine synthetase. | 0.942 |
| ISM_11415 | ISM_11430 | ISM_11415 | ISM_11430 | Hypothetical protein; COG1454 Alcohol dehydrogenase, class IV. | Bacterial extracellular solute-binding protein, family 7 protein; COG4663 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component. | 0.863 |