| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_07430 | ISM_11490 | ISM_07430 | ISM_11490 | Exodeoxyribonuclease III, putative; COG0708 Exonuclease III. | COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. | 0.700 |
| ISM_07430 | ISM_16465 | ISM_07430 | ISM_16465 | Exodeoxyribonuclease III, putative; COG0708 Exonuclease III. | COG0708 Exonuclease III. | 0.929 |
| ISM_07430 | tadA | ISM_07430 | ISM_11495 | Exodeoxyribonuclease III, putative; COG0708 Exonuclease III. | Cytidine and deoxycytidylate deaminase family protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.733 |
| ISM_11230 | ISM_13635 | ISM_11230 | ISM_13635 | COG0402 Cytosine deaminase and related metal-dependent hydrolases. | COG0167 Dihydroorotate dehydrogenase. | 0.839 |
| ISM_11230 | ISM_14885 | ISM_11230 | ISM_14885 | COG0402 Cytosine deaminase and related metal-dependent hydrolases. | Xanthine dehydrogenase family protein, small/large subunits; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. | 0.693 |
| ISM_11230 | ISM_15450 | ISM_11230 | ISM_15450 | COG0402 Cytosine deaminase and related metal-dependent hydrolases. | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | 0.561 |
| ISM_11230 | tadA | ISM_11230 | ISM_11495 | COG0402 Cytosine deaminase and related metal-dependent hydrolases. | Cytidine and deoxycytidylate deaminase family protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.816 |
| ISM_11230 | upp | ISM_11230 | ISM_09591 | COG0402 Cytosine deaminase and related metal-dependent hydrolases. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.930 |
| ISM_11490 | ISM_07430 | ISM_11490 | ISM_07430 | COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. | Exodeoxyribonuclease III, putative; COG0708 Exonuclease III. | 0.700 |
| ISM_11490 | ISM_16465 | ISM_11490 | ISM_16465 | COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. | COG0708 Exonuclease III. | 0.700 |
| ISM_11490 | tadA | ISM_11490 | ISM_11495 | COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Belongs to the pseudouridine synthase RsuA family. | Cytidine and deoxycytidylate deaminase family protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.709 |
| ISM_13635 | ISM_11230 | ISM_13635 | ISM_11230 | COG0167 Dihydroorotate dehydrogenase. | COG0402 Cytosine deaminase and related metal-dependent hydrolases. | 0.839 |
| ISM_13635 | ISM_14885 | ISM_13635 | ISM_14885 | COG0167 Dihydroorotate dehydrogenase. | Xanthine dehydrogenase family protein, small/large subunits; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. | 0.838 |
| ISM_13635 | ISM_15450 | ISM_13635 | ISM_15450 | COG0167 Dihydroorotate dehydrogenase. | COG1957 Inosine-uridine nucleoside N-ribohydrolase. | 0.479 |
| ISM_13635 | ribB | ISM_13635 | ISM_00120 | COG0167 Dihydroorotate dehydrogenase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.576 |
| ISM_13635 | tadA | ISM_13635 | ISM_11495 | COG0167 Dihydroorotate dehydrogenase. | Cytidine and deoxycytidylate deaminase family protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.711 |
| ISM_13635 | upp | ISM_13635 | ISM_09591 | COG0167 Dihydroorotate dehydrogenase. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.955 |
| ISM_14885 | ISM_11230 | ISM_14885 | ISM_11230 | Xanthine dehydrogenase family protein, small/large subunits; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. | COG0402 Cytosine deaminase and related metal-dependent hydrolases. | 0.693 |
| ISM_14885 | ISM_13635 | ISM_14885 | ISM_13635 | Xanthine dehydrogenase family protein, small/large subunits; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. | COG0167 Dihydroorotate dehydrogenase. | 0.838 |
| ISM_14885 | tadA | ISM_14885 | ISM_11495 | Xanthine dehydrogenase family protein, small/large subunits; COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs. | Cytidine and deoxycytidylate deaminase family protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.751 |