STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM_11660Phosphate transporter family protein; COG0306 Phosphate/sulphate permeases. (493 aa)    
Predicted Functional Partners:
cysC
Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate.
  
  
 0.812
ISM_15725
uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
  
  
 0.727
ISM_11665
Hydrolase, NUDIX family protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes.
 
  
 0.723
ISM_11655
Hypothetical protein.
       0.531
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
   
    0.499
ISM_16730
Non-ribosomal peptide synthetase; COG0223 Methionyl-tRNA formyltransferase.
  
  
 0.485
ISM_06100
Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1.
     
 0.448
ISM_06485
OmpA domain protein; COG0226 ABC-type phosphate transport system, periplasmic component.
     
 0.442
ISM_12905
Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain.
     
 0.438
ISM_13260
COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis.
   
    0.438
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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