| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_00345 | ISM_09636 | ISM_00345 | ISM_09636 | DnaJ domain protein; COG2214 DnaJ-class molecular chaperone. | COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | 0.700 |
| ISM_00345 | ISM_10810 | ISM_00345 | ISM_10810 | DnaJ domain protein; COG2214 DnaJ-class molecular chaperone. | Molecular chaperone, DnaK; COG0443 Molecular chaperone. | 0.993 |
| ISM_00345 | ISM_11050 | ISM_00345 | ISM_11050 | DnaJ domain protein; COG2214 DnaJ-class molecular chaperone. | COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | 0.739 |
| ISM_00345 | ISM_11700 | ISM_00345 | ISM_11700 | DnaJ domain protein; COG2214 DnaJ-class molecular chaperone. | ATP-dependent Clp protease, ATP-binding subunit ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.870 |
| ISM_00345 | clpP | ISM_00345 | ISM_01310 | DnaJ domain protein; COG2214 DnaJ-class molecular chaperone. | Protease subunit of ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.703 |
| ISM_00345 | dnaK | ISM_00345 | ISM_08455 | DnaJ domain protein; COG2214 DnaJ-class molecular chaperone. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.995 |
| ISM_00345 | grpE | ISM_00345 | ISM_06685 | DnaJ domain protein; COG2214 DnaJ-class molecular chaperone. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.951 |
| ISM_09636 | ISM_00345 | ISM_09636 | ISM_00345 | COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | DnaJ domain protein; COG2214 DnaJ-class molecular chaperone. | 0.700 |
| ISM_09636 | ISM_10810 | ISM_09636 | ISM_10810 | COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Molecular chaperone, DnaK; COG0443 Molecular chaperone. | 0.577 |
| ISM_09636 | ISM_11700 | ISM_09636 | ISM_11700 | COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease, ATP-binding subunit ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.862 |
| ISM_09636 | dnaJ | ISM_09636 | ISM_08460 | COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.713 |
| ISM_09636 | dnaK | ISM_09636 | ISM_08455 | COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.685 |
| ISM_09636 | grpE | ISM_09636 | ISM_06685 | COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.659 |
| ISM_10810 | ISM_00345 | ISM_10810 | ISM_00345 | Molecular chaperone, DnaK; COG0443 Molecular chaperone. | DnaJ domain protein; COG2214 DnaJ-class molecular chaperone. | 0.993 |
| ISM_10810 | ISM_09636 | ISM_10810 | ISM_09636 | Molecular chaperone, DnaK; COG0443 Molecular chaperone. | COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | 0.577 |
| ISM_10810 | ISM_11050 | ISM_10810 | ISM_11050 | Molecular chaperone, DnaK; COG0443 Molecular chaperone. | COG0071 Molecular chaperone (small heat shock protein); Belongs to the small heat shock protein (HSP20) family. | 0.577 |
| ISM_10810 | ISM_11700 | ISM_10810 | ISM_11700 | Molecular chaperone, DnaK; COG0443 Molecular chaperone. | ATP-dependent Clp protease, ATP-binding subunit ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.976 |
| ISM_10810 | clpP | ISM_10810 | ISM_01310 | Molecular chaperone, DnaK; COG0443 Molecular chaperone. | Protease subunit of ATP-dependent Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.747 |
| ISM_10810 | clpS | ISM_10810 | ISM_07965 | Molecular chaperone, DnaK; COG0443 Molecular chaperone. | ATP-dependent Clp protease, adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.429 |
| ISM_10810 | dnaJ | ISM_10810 | ISM_08460 | Molecular chaperone, DnaK; COG0443 Molecular chaperone. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.994 |
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