Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ISM_12140HflK protein; HflC and HflK could encode or regulate a protease. (381 aa)    
Predicted Functional Partners:
ISM_12145
HflC protein; HflC and HflK could regulate a protease.
 
 
 0.998
ftsH
ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
 0.957
hflX
GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
  
  
 0.854
ISM_12150
Hypothetical protein.
     
 0.845
yidC
Inner membrane protein YidC, putative; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
 
 
 0.817
ISM_12135
Glutathione-disulfide reductase; Maintains high levels of reduced glutathione.
  
 
 0.761
ISM_03090
Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family.
  
 0.692
ISM_06460
Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family.
  
 0.692
ISM_06465
Peptidase, M16 family protein; COG0612 Predicted Zn-dependent peptidases.
  
 0.692
ISM_12040
Membrane protein, putative.
   
 0.658
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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