Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_12185Tellurite resistance protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes. (312 aa)    
Predicted Functional Partners:
prs
Phosphoribosyl pyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
    
 0.867
ISM_02820
Phosphomannomutase/phosphoglucomutase; COG1109 Phosphomannomutase.
    
  0.851
ISM_12180
Tellurite resistance protein; COG0477 Permeases of the major facilitator superfamily.
       0.845
nnrD
YjeF family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...]
  
 0.781
ISM_12200
Alanyl-transfer RNA synthetase domain protein; COG2872 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain.
       0.727
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
   
 0.717
ISM_12190
COG0031 Cysteine synthase.
     
 0.701
ISM_12175
COG0415 Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family.
   
   0.663
ISM_12195
COG3264 Small-conductance mechanosensitive channel.
       0.634
ISM_03735
Putative ATP-dependent RNA helicase protein; COG0513 Superfamily II DNA and RNA helicases.
    
 0.631
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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