STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM_12210Putative Na+/H+ antiporter with cyclic nucleotide-binding domain; COG0025 NhaP-type Na+/H+ and K+/H+ antiporters. (822 aa)    
Predicted Functional Partners:
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
 0.831
ISM_06100
Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1.
    
 0.805
ISM_17225
Glutathione-regulated potassium-efflux system protein; COG0475 Kef-type K+ transport systems, membrane components.
   
 
 0.782
ISM_06925
Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase.
   
 0.696
ISM_10036
K+-dependent Na+/Ca+ exchanger related-protein; COG0530 Ca2+/Na+ antiporter.
   
 
 0.667
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.650
ISM_04775
Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase.
   
 0.640
ISM_05545
Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain.
   
 0.640
ISM_12040
Membrane protein, putative.
  
 
 0.619
ISM_05910
Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase.
   
 0.610
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.