| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_04975 | ISM_04990 | ISM_04975 | ISM_04990 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.999 |
| ISM_04975 | ISM_04995 | ISM_04975 | ISM_04995 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | COG2142 Succinate dehydrogenase, hydrophobic anchor subunit. | 0.997 |
| ISM_04975 | ISM_06040 | ISM_04975 | ISM_06040 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.994 |
| ISM_04975 | ISM_12310 | ISM_04975 | ISM_12310 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. | 0.676 |
| ISM_04975 | ISM_12315 | ISM_04975 | ISM_12315 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Putative succinate dehydrogenase membrane anchor; COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | 0.957 |
| ISM_04975 | ISM_12320 | ISM_04975 | ISM_12320 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | 0.973 |
| ISM_04975 | ISM_12325 | ISM_04975 | ISM_12325 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. | 0.727 |
| ISM_04975 | ISM_12330 | ISM_04975 | ISM_12330 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain. | 0.658 |
| ISM_04975 | ISM_12340 | ISM_04975 | ISM_12340 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain. | 0.676 |
| ISM_04975 | nuoD | ISM_04975 | ISM_14300 | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | NADH dehydrogenase delta subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. | 0.916 |
| ISM_04990 | ISM_04975 | ISM_04990 | ISM_04975 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.999 |
| ISM_04990 | ISM_04995 | ISM_04990 | ISM_04995 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG2142 Succinate dehydrogenase, hydrophobic anchor subunit. | 0.999 |
| ISM_04990 | ISM_06040 | ISM_04990 | ISM_06040 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.997 |
| ISM_04990 | ISM_12310 | ISM_04990 | ISM_12310 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit. | 0.997 |
| ISM_04990 | ISM_12315 | ISM_04990 | ISM_12315 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Putative succinate dehydrogenase membrane anchor; COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | 0.984 |
| ISM_04990 | ISM_12320 | ISM_04990 | ISM_12320 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit. | 0.992 |
| ISM_04990 | ISM_12325 | ISM_04990 | ISM_12325 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit. | 0.792 |
| ISM_04990 | ISM_12330 | ISM_04990 | ISM_12330 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain. | 0.839 |
| ISM_04990 | ISM_12340 | ISM_04990 | ISM_12340 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain. | 0.854 |
| ISM_04990 | nuoD | ISM_04990 | ISM_14300 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | NADH dehydrogenase delta subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. | 0.932 |