Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_12330COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain. (319 aa)    
Predicted Functional Partners:
ISM_12340
COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain.
 
 0.998
ISM_12315
Putative succinate dehydrogenase membrane anchor; COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit.
 
 
 0.983
ISM_12320
COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit.
 
 
 0.983
ISM_12310
COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit.
 
 
 0.979
ISM_12325
COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit.
 
  
  0.977
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 
 0.918
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
  
 0.887
ISM_14750
COG0372 Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.887
ISM_12335
L-carnitine dehydratase/bile acid-inducible protein F; COG1804 Predicted acyl-CoA transferases/carnitine dehydratase; Belongs to the CoA-transferase III family.
    
  0.856
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.852
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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