Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_12405GGDEF; COG2199 FOG: GGDEF domain. (290 aa)    
Predicted Functional Partners:
ISM_09486
COG2200 FOG: EAL domain.
 
 0.986
ISM_05685
Hypothetical protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.
 
0.922
ISM_05265
Diguanylate cyclase, putative; COG2200 FOG: EAL domain.
 
 0.886
ISM_06625
Response regulator; COG0784 FOG: CheY-like receiver.
 
 
 0.858
ISM_06925
Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase.
 
 0.831
ISM_10161
Anti-sigma B factor, putative; COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase).
   
 
 0.692
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
 
  
 0.665
ISM_07425
Putative two-component system sensor histidine kinase; COG2203 FOG: GAF domain.
 
 0.642
ISM_11995
Diguanylate cyclase, putative/response regulator; COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain.
 
 
0.641
ISM_11350
COG1536 Flagellar motor switch protein.
  
  
 0.619
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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