| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_08180 | ISM_12615 | ISM_08180 | ISM_12615 | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | CobG; COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.874 |
| ISM_08180 | ISM_15740 | ISM_08180 | ISM_15740 | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.724 |
| ISM_08180 | cysC | ISM_08180 | ISM_11065 | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | Bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Catalyzes the synthesis of activated sulfate. | 0.435 |
| ISM_12600 | ISM_12610 | ISM_12600 | ISM_12610 | COG5469 Predicted metal-binding protein. | Cobaltochelatase; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | 0.931 |
| ISM_12600 | ISM_12615 | ISM_12600 | ISM_12615 | COG5469 Predicted metal-binding protein. | CobG; COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.942 |
| ISM_12600 | ISM_12620 | ISM_12600 | ISM_12620 | COG5469 Predicted metal-binding protein. | precorrin-8X methylmutase; COG2082 Precorrin isomerase. | 0.844 |
| ISM_12600 | ISM_12625 | ISM_12600 | ISM_12625 | COG5469 Predicted metal-binding protein. | COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. | 0.905 |
| ISM_12600 | ISM_12630 | ISM_12600 | ISM_12630 | COG5469 Predicted metal-binding protein. | COG1010 Precorrin-3B methylase. | 0.867 |
| ISM_12600 | ISM_12640 | ISM_12600 | ISM_12640 | COG5469 Predicted metal-binding protein. | precorrin-6Y C5,15-methyltransferase (decarboxylating); COG2241 Precorrin-6B methylase 1. | 0.601 |
| ISM_12610 | ISM_12600 | ISM_12610 | ISM_12600 | Cobaltochelatase; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | COG5469 Predicted metal-binding protein. | 0.931 |
| ISM_12610 | ISM_12615 | ISM_12610 | ISM_12615 | Cobaltochelatase; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | CobG; COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.964 |
| ISM_12610 | ISM_12620 | ISM_12610 | ISM_12620 | Cobaltochelatase; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | precorrin-8X methylmutase; COG2082 Precorrin isomerase. | 0.976 |
| ISM_12610 | ISM_12625 | ISM_12610 | ISM_12625 | Cobaltochelatase; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | COG2243 Precorrin-2 methylase; Belongs to the precorrin methyltransferase family. | 0.968 |
| ISM_12610 | ISM_12630 | ISM_12610 | ISM_12630 | Cobaltochelatase; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | COG1010 Precorrin-3B methylase. | 0.969 |
| ISM_12610 | ISM_12640 | ISM_12610 | ISM_12640 | Cobaltochelatase; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | precorrin-6Y C5,15-methyltransferase (decarboxylating); COG2241 Precorrin-6B methylase 1. | 0.965 |
| ISM_12610 | ISM_15725 | ISM_12610 | ISM_15725 | Cobaltochelatase; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.549 |
| ISM_12615 | ISM_08180 | ISM_12615 | ISM_08180 | CobG; COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.874 |
| ISM_12615 | ISM_12600 | ISM_12615 | ISM_12600 | CobG; COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | COG5469 Predicted metal-binding protein. | 0.942 |
| ISM_12615 | ISM_12610 | ISM_12615 | ISM_12610 | CobG; COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Cobaltochelatase; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases. | 0.964 |
| ISM_12615 | ISM_12620 | ISM_12615 | ISM_12620 | CobG; COG0155 Sulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | precorrin-8X methylmutase; COG2082 Precorrin isomerase. | 0.986 |