STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobB-2Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (439 aa)    
Predicted Functional Partners:
ISM_12620
precorrin-8X methylmutase; COG2082 Precorrin isomerase.
 
 
 0.995
ISM_12640
precorrin-6Y C5,15-methyltransferase (decarboxylating); COG2241 Precorrin-6B methylase 1.
 
  
 0.985
ISM_12610
Cobaltochelatase; COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases.
 
 
 0.984
ISM_12650
COG2875 Precorrin-4 methylase; Belongs to the precorrin methyltransferase family.
 
  
 0.984
cobQ
Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 0.979
ISM_08445
cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.
 
 
 0.975
ISM_12645
Cobalamin biosynthesis domain protein; COG0183 Acetyl-CoA acetyltransferase.
 
  
 0.968
ISM_12635
COG2099 Precorrin-6x reductase.
 
  
 0.955
ISM_00370
Cobalt chelatase, CobS subunit; COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain.
     
  0.952
ISM_00380
Cobalt chelatase, pCobT subunit; COG0436 Aspartate/tyrosine/aromatic aminotransferase.
     
  0.952
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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