| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_01450 | ISM_01455 | COG2086 Electron transfer flavoprotein, beta subunit. | COG2025 Electron transfer flavoprotein, alpha subunit. | 0.999 |
| ISM_01450 | ISM_08180 | COG2086 Electron transfer flavoprotein, beta subunit. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.559 |
| ISM_01450 | ISM_12680 | COG2086 Electron transfer flavoprotein, beta subunit. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.984 |
| ISM_01455 | ISM_01450 | COG2025 Electron transfer flavoprotein, alpha subunit. | COG2086 Electron transfer flavoprotein, beta subunit. | 0.999 |
| ISM_01455 | ISM_08180 | COG2025 Electron transfer flavoprotein, alpha subunit. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.429 |
| ISM_01455 | ISM_12680 | COG2025 Electron transfer flavoprotein, alpha subunit. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.964 |
| ISM_06100 | ISM_07475 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | 0.978 |
| ISM_06100 | ISM_08180 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.405 |
| ISM_06100 | ISM_12680 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.999 |
| ISM_06100 | ISM_15335 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Glutamine amidotransferase-like protein; COG0067 Glutamate synthase domain 1. | 0.979 |
| ISM_06100 | ISM_15340 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | GXGXG motif-containing protein; COG0070 Glutamate synthase domain 3. | 0.971 |
| ISM_06100 | ISM_16940 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | FwdC/FmdC family protein; COG0070 Glutamate synthase domain 3. | 0.971 |
| ISM_06100 | ISM_16945 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Glutamine amidotransferase, class II; COG0067 Glutamate synthase domain 1. | 0.979 |
| ISM_07105 | ISM_12680 | Iron-sulfur cluster-binding protein; COG0633 Ferredoxin. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.921 |
| ISM_07475 | ISM_06100 | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.978 |
| ISM_07475 | ISM_12680 | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.920 |
| ISM_07475 | ISM_15335 | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | Glutamine amidotransferase-like protein; COG0067 Glutamate synthase domain 1. | 0.848 |
| ISM_07475 | ISM_15340 | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | GXGXG motif-containing protein; COG0070 Glutamate synthase domain 3. | 0.795 |
| ISM_07475 | ISM_16940 | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | FwdC/FmdC family protein; COG0070 Glutamate synthase domain 3. | 0.794 |
| ISM_07475 | ISM_16945 | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | Glutamine amidotransferase, class II; COG0067 Glutamate synthase domain 1. | 0.848 |