| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_01215 | ISM_03765 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.453 |
| ISM_01215 | ISM_04770 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component response regulator; COG0784 FOG: CheY-like receiver. | 0.723 |
| ISM_01215 | ISM_04775 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.957 |
| ISM_01215 | ISM_04790 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sigma factor sigB regulation protein rsbU; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.825 |
| ISM_01215 | ISM_05545 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.831 |
| ISM_01215 | ISM_05910 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.852 |
| ISM_01215 | ISM_06925 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.891 |
| ISM_01215 | ISM_07425 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Putative two-component system sensor histidine kinase; COG2203 FOG: GAF domain. | 0.559 |
| ISM_01215 | ISM_12905 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.934 |
| ISM_01215 | ISM_15615 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Phosphate regulon transcriptional regulatory protein PhoB; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.407 |
| ISM_03765 | ISM_01215 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.453 |
| ISM_03765 | ISM_04770 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component response regulator; COG0784 FOG: CheY-like receiver. | 0.475 |
| ISM_03765 | ISM_04775 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.959 |
| ISM_03765 | ISM_05545 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.831 |
| ISM_03765 | ISM_05910 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.830 |
| ISM_03765 | ISM_06925 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.888 |
| ISM_03765 | ISM_07425 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Putative two-component system sensor histidine kinase; COG2203 FOG: GAF domain. | 0.559 |
| ISM_03765 | ISM_12905 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.932 |
| ISM_04770 | ISM_01215 | Two-component response regulator; COG0784 FOG: CheY-like receiver. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.723 |
| ISM_04770 | ISM_03765 | Two-component response regulator; COG0784 FOG: CheY-like receiver. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.475 |