| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_07345 | ISM_11795 | ISM_07345 | ISM_11795 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | 0.768 |
| ISM_07345 | ISM_13050 | ISM_07345 | ISM_13050 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | COG0307 Riboflavin synthase alpha chain. | 0.542 |
| ISM_07345 | ribB | ISM_07345 | ISM_00120 | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.485 |
| ISM_09861 | ISM_13030 | ISM_09861 | ISM_13030 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.697 |
| ISM_09861 | ISM_13050 | ISM_09861 | ISM_13050 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | COG0307 Riboflavin synthase alpha chain. | 0.474 |
| ISM_09861 | ribB | ISM_09861 | ISM_00120 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.609 |
| ISM_09861 | ribH | ISM_09861 | ISM_10606 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Riboflavin synthase subunit beta; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.493 |
| ISM_09861 | ribH-2 | ISM_09861 | ISM_00115 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.651 |
| ISM_11795 | ISM_07345 | ISM_11795 | ISM_07345 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | 4-hydroxyphenylacetate 3-monooxygenase; COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family. | 0.768 |
| ISM_11795 | ISM_13030 | ISM_11795 | ISM_13030 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.696 |
| ISM_11795 | ISM_13050 | ISM_11795 | ISM_13050 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | COG0307 Riboflavin synthase alpha chain. | 0.950 |
| ISM_11795 | ribA | ISM_11795 | ISM_07415 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. | 0.489 |
| ISM_11795 | ribB | ISM_11795 | ISM_00120 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.843 |
| ISM_11795 | ribH | ISM_11795 | ISM_10606 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | Riboflavin synthase subunit beta; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.584 |
| ISM_11795 | ribH-2 | ISM_11795 | ISM_00115 | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.412 |
| ISM_13030 | ISM_09861 | ISM_13030 | ISM_09861 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.697 |
| ISM_13030 | ISM_11795 | ISM_13030 | ISM_11795 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family. | 0.696 |
| ISM_13030 | ISM_13050 | ISM_13030 | ISM_13050 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COG0307 Riboflavin synthase alpha chain. | 0.999 |
| ISM_13030 | ndk | ISM_13030 | ISM_17040 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.772 |
| ISM_13030 | ribA | ISM_13030 | ISM_07415 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. | 0.999 |