| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00215 | ISM_04775 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.959 |
| ISM_00215 | ISM_06625 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Response regulator; COG0784 FOG: CheY-like receiver. | 0.985 |
| ISM_00215 | ISM_06925 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.996 |
| ISM_00215 | ISM_09296 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Putative two-component sensor histidine kinase protein; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system. | 0.748 |
| ISM_00215 | ISM_11180 | Hypothetical protein; COG2199 FOG: GGDEF domain. | C4-dicarboxylate transport sensor protein dctB; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system. | 0.752 |
| ISM_00215 | ISM_12905 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.861 |
| ISM_00215 | ISM_13495 | Hypothetical protein; COG2199 FOG: GGDEF domain. | C4-dicarboxylate transport sensor protein DctB, putative; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system. | 0.749 |
| ISM_00215 | ISM_13500 | Hypothetical protein; COG2199 FOG: GGDEF domain. | C4-dicarboxylate transport transcriptional regulatory protein DctD; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.668 |
| ISM_00215 | ISM_16630 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Nitrogen regulation protein ntrY; COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | 0.480 |
| ISM_00215 | ISM_16640 | Hypothetical protein; COG2199 FOG: GGDEF domain. | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | 0.437 |
| ISM_04775 | ISM_00215 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Hypothetical protein; COG2199 FOG: GGDEF domain. | 0.959 |
| ISM_04775 | ISM_06625 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Response regulator; COG0784 FOG: CheY-like receiver. | 0.990 |
| ISM_04775 | ISM_06925 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.998 |
| ISM_04775 | ISM_09296 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Putative two-component sensor histidine kinase protein; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system. | 0.659 |
| ISM_04775 | ISM_11180 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | C4-dicarboxylate transport sensor protein dctB; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system. | 0.659 |
| ISM_04775 | ISM_12905 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Multi-sensor Signal Transduction Histidine Kinase; COG2202 FOG: PAS/PAC domain. | 0.963 |
| ISM_04775 | ISM_13495 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | C4-dicarboxylate transport sensor protein DctB, putative; COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system. | 0.659 |
| ISM_04775 | ISM_13500 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | C4-dicarboxylate transport transcriptional regulatory protein DctD; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.624 |
| ISM_04775 | ISM_16630 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Nitrogen regulation protein ntrY; COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | 0.704 |
| ISM_04775 | ISM_16640 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | 0.820 |