| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_06100 | ISM_07475 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | 0.978 |
| ISM_06100 | ISM_08180 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.405 |
| ISM_06100 | ISM_13640 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Pyridine nucleotide-disulphide oxidoreductase family protein; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | 0.999 |
| ISM_06100 | ISM_15335 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Glutamine amidotransferase-like protein; COG0067 Glutamate synthase domain 1. | 0.979 |
| ISM_06100 | ISM_15340 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | GXGXG motif-containing protein; COG0070 Glutamate synthase domain 3. | 0.971 |
| ISM_06100 | ISM_15345 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Glutamate synthase large subunit-like protein; COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | 0.979 |
| ISM_06100 | ISM_16935 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | 0.978 |
| ISM_07105 | ISM_13640 | Iron-sulfur cluster-binding protein; COG0633 Ferredoxin. | Pyridine nucleotide-disulphide oxidoreductase family protein; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | 0.915 |
| ISM_07475 | ISM_06100 | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.978 |
| ISM_07475 | ISM_13640 | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | Pyridine nucleotide-disulphide oxidoreductase family protein; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | 0.905 |
| ISM_07475 | ISM_15335 | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | Glutamine amidotransferase-like protein; COG0067 Glutamate synthase domain 1. | 0.848 |
| ISM_07475 | ISM_15340 | COG0069 Glutamate synthase domain 2; Belongs to the glutamate synthase family. | GXGXG motif-containing protein; COG0070 Glutamate synthase domain 3. | 0.795 |
| ISM_08180 | ISM_06100 | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.405 |
| ISM_08180 | ISM_13635 | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | COG0167 Dihydroorotate dehydrogenase. | 0.746 |
| ISM_08180 | ISM_13640 | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | Pyridine nucleotide-disulphide oxidoreductase family protein; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | 0.926 |
| ISM_13615 | ISM_13635 | Dihydropyrimidinase; COG0044 Dihydroorotase and related cyclic amidohydrolases. | COG0167 Dihydroorotate dehydrogenase. | 0.994 |
| ISM_13615 | ISM_13640 | Dihydropyrimidinase; COG0044 Dihydroorotase and related cyclic amidohydrolases. | Pyridine nucleotide-disulphide oxidoreductase family protein; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | 0.977 |
| ISM_13635 | ISM_08180 | COG0167 Dihydroorotate dehydrogenase. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.746 |
| ISM_13635 | ISM_13615 | COG0167 Dihydroorotate dehydrogenase. | Dihydropyrimidinase; COG0044 Dihydroorotase and related cyclic amidohydrolases. | 0.994 |
| ISM_13635 | ISM_13640 | COG0167 Dihydroorotate dehydrogenase. | Pyridine nucleotide-disulphide oxidoreductase family protein; COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. | 0.999 |