STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM_13835Hypothetical protein. (249 aa)    
Predicted Functional Partners:
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.812
ISM_11880
Alkylphosphonate utilization protein PhnM, putative; COG3454 Metal-dependent hydrolase involved in phosphonate metabolism.
 
     0.805
ISM_06225
Alkylphosphonate utilization protein PhnM; COG3454 Metal-dependent hydrolase involved in phosphonate metabolism.
 
     0.794
ISM_06250
Alkylphosphonate utilization protein PhnI; COG3626 Uncharacterized enzyme of phosphonate metabolism.
 
     0.753
ISM_06245
Alkylphosphonate utilization protein PhnJ; Catalyzes the breakage of the C-P bond in alpha-D-ribose 1- methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose. Belongs to the PhnJ family.
 
     0.749
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.745
ISM_06260
Alkylphosphonate utilization protein PhnG; COG3624 Uncharacterized enzyme of phosphonate metabolism.
 
     0.730
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 0.721
ISM_06240
Alkylphosphonate utilization protein PhnK; COG4107 ABC-type phosphonate transport system, ATPase component.
 
     0.710
ISM_06255
Alkylphosphonate utilization protein PhnH; COG3625 Uncharacterized enzyme of phosphonate metabolism.
 
     0.703
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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