| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_00390 | ISM_13925 | ISM_00390 | ISM_13925 | COG0006 Xaa-Pro aminopeptidase; Belongs to the peptidase M24B family. | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | 0.523 |
| ISM_04190 | ISM_13925 | ISM_04190 | ISM_13925 | Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | 0.626 |
| ISM_07880 | ISM_13925 | ISM_07880 | ISM_13925 | Hypothetical protein; COG0006 Xaa-Pro aminopeptidase. | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | 0.585 |
| ISM_08325 | ISM_13925 | ISM_08325 | ISM_13925 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | 0.642 |
| ISM_08325 | ISM_13930 | ISM_08325 | ISM_13930 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Glutamate/leucine/phenylalanine/valine dehydrogenase family protein; COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.856 |
| ISM_10271 | ISM_13925 | ISM_10271 | ISM_13925 | Putative aminotransferase protein; COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | 0.626 |
| ISM_10765 | ISM_13925 | ISM_10765 | ISM_13925 | Creatinase; COG0006 Xaa-Pro aminopeptidase. | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | 0.523 |
| ISM_13925 | ISM_00390 | ISM_13925 | ISM_00390 | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | COG0006 Xaa-Pro aminopeptidase; Belongs to the peptidase M24B family. | 0.523 |
| ISM_13925 | ISM_04190 | ISM_13925 | ISM_04190 | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.626 |
| ISM_13925 | ISM_07880 | ISM_13925 | ISM_07880 | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | Hypothetical protein; COG0006 Xaa-Pro aminopeptidase. | 0.585 |
| ISM_13925 | ISM_08325 | ISM_13925 | ISM_08325 | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.642 |
| ISM_13925 | ISM_10271 | ISM_13925 | ISM_10271 | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | Putative aminotransferase protein; COG0160 4-aminobutyrate aminotransferase and related aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.626 |
| ISM_13925 | ISM_10765 | ISM_13925 | ISM_10765 | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | Creatinase; COG0006 Xaa-Pro aminopeptidase. | 0.523 |
| ISM_13925 | ISM_13930 | ISM_13925 | ISM_13930 | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | Glutamate/leucine/phenylalanine/valine dehydrogenase family protein; COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.535 |
| ISM_13925 | ISM_15490 | ISM_13925 | ISM_15490 | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | Possible ribosomal protein S6 modification protein; COG4067 Uncharacterized protein conserved in archaea. | 0.810 |
| ISM_13925 | ISM_17155 | ISM_13925 | ISM_17155 | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | Metallopeptidase, family M24; COG0006 Xaa-Pro aminopeptidase. | 0.523 |
| ISM_13925 | dddP | ISM_13925 | ISM_05385 | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | Metallopeptidase, family M24; Able to cleave dimethlysulfonioproprionate (DMSP), releasing dimethyl sulfide (DMS). DMS is the principal form by which sulfur is transported from oceans to the atmosphere. The real activity of the protein is however subject to debate and it is unclear whether it constitutes a real dimethlysulfonioproprionate lyase in vivo: the low activity with DMSP as substrate suggests that DMSP is not its native substrate. | 0.523 |
| ISM_13930 | ISM_08325 | ISM_13930 | ISM_08325 | Glutamate/leucine/phenylalanine/valine dehydrogenase family protein; COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.856 |
| ISM_13930 | ISM_13925 | ISM_13930 | ISM_13925 | Glutamate/leucine/phenylalanine/valine dehydrogenase family protein; COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | 0.535 |
| ISM_15490 | ISM_13925 | ISM_15490 | ISM_13925 | Possible ribosomal protein S6 modification protein; COG4067 Uncharacterized protein conserved in archaea. | Succinylglutamate desuccinylase/aspartoacylase; COG3608 Predicted deacylase. | 0.810 |