| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_02055 | ISM_04105 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.836 |
| ISM_02055 | ISM_06905 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | Beta-ketothiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.689 |
| ISM_02055 | ISM_14245 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). | 0.552 |
| ISM_02055 | ISM_14255 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. | 0.577 |
| ISM_02055 | ISM_14265 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. | 0.795 |
| ISM_02055 | ISM_14270 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.829 |
| ISM_02055 | ISM_14745 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | enoyl-CoA hydratase/isomerase family protein; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.836 |
| ISM_04080 | ISM_04105 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.911 |
| ISM_04080 | ISM_14245 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). | 0.552 |
| ISM_04080 | ISM_14255 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. | 0.577 |
| ISM_04080 | ISM_14265 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. | 0.576 |
| ISM_04080 | ISM_14270 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.829 |
| ISM_04080 | ISM_14745 | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | enoyl-CoA hydratase/isomerase family protein; COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.836 |
| ISM_04105 | ISM_02055 | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.836 |
| ISM_04105 | ISM_04080 | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.911 |
| ISM_04105 | ISM_05910 | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.961 |
| ISM_04105 | ISM_06905 | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | Beta-ketothiolase; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.836 |
| ISM_04105 | ISM_06925 | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.971 |
| ISM_04105 | ISM_14245 | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). | 0.596 |
| ISM_04105 | ISM_14255 | COG1024 Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. | COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. | 0.634 |