| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_10685 | ISM_12355 | ISM_10685 | ISM_12355 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | COG1832 Predicted CoA-binding protein. | 0.546 |
| ISM_10685 | ISM_12920 | ISM_10685 | ISM_12920 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | COG0460 Homoserine dehydrogenase. | 0.786 |
| ISM_10685 | ISM_13465 | ISM_10685 | ISM_13465 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | Homocysteine S-methyltransferase family protein; COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | 0.927 |
| ISM_10685 | ISM_13720 | ISM_10685 | ISM_13720 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | Putative aminotransferase; COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. | 0.910 |
| ISM_10685 | ISM_14405 | ISM_10685 | ISM_14405 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | COG2873 O-acetylhomoserine sulfhydrylase. | 0.911 |
| ISM_10685 | ISM_15115 | ISM_10685 | ISM_15115 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | Hypothetical protein; COG1410 Methionine synthase I, cobalamin-binding domain. | 0.890 |
| ISM_10685 | ahcY | ISM_10685 | ISM_06880 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.822 |
| ISM_10685 | metAA | ISM_10685 | ISM_16275 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.958 |
| ISM_10685 | metK | ISM_10685 | ISM_00720 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.755 |
| ISM_10685 | metZ | ISM_10685 | ISM_06080 | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.880 |
| ISM_12355 | ISM_10685 | ISM_12355 | ISM_10685 | COG1832 Predicted CoA-binding protein. | COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. | 0.546 |
| ISM_12355 | ISM_12920 | ISM_12355 | ISM_12920 | COG1832 Predicted CoA-binding protein. | COG0460 Homoserine dehydrogenase. | 0.427 |
| ISM_12355 | ISM_13465 | ISM_12355 | ISM_13465 | COG1832 Predicted CoA-binding protein. | Homocysteine S-methyltransferase family protein; COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain. | 0.427 |
| ISM_12355 | ISM_13720 | ISM_12355 | ISM_13720 | COG1832 Predicted CoA-binding protein. | Putative aminotransferase; COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities. | 0.427 |
| ISM_12355 | ISM_14405 | ISM_12355 | ISM_14405 | COG1832 Predicted CoA-binding protein. | COG2873 O-acetylhomoserine sulfhydrylase. | 0.948 |
| ISM_12355 | ISM_15115 | ISM_12355 | ISM_15115 | COG1832 Predicted CoA-binding protein. | Hypothetical protein; COG1410 Methionine synthase I, cobalamin-binding domain. | 0.427 |
| ISM_12355 | ahcY | ISM_12355 | ISM_06880 | COG1832 Predicted CoA-binding protein. | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.429 |
| ISM_12355 | metAA | ISM_12355 | ISM_16275 | COG1832 Predicted CoA-binding protein. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.438 |
| ISM_12355 | metK | ISM_12355 | ISM_00720 | COG1832 Predicted CoA-binding protein. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.465 |
| ISM_12355 | metZ | ISM_12355 | ISM_06080 | COG1832 Predicted CoA-binding protein. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.772 |