Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
ISM_14620COG1393 Arsenate reductase and related proteins, glutaredoxin family. (140 aa)    
Predicted Functional Partners:
ISM_14615
NADPH-dependent FMN reductase; COG0431 Predicted flavoprotein.
 
   
 0.903
ISM_14630
Arsenate reductase; COG0394 Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
 
  
 0.856
ISM_14635
Transcriptional regulator, ArsR family protein; COG0640 Predicted transcriptional regulators.
 
   
 0.825
ISM_14625
COG0798 Arsenite efflux pump ACR3 and related permeases.
     
 0.816
rpoA
DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
   0.694
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
     
  0.630
ISM_04370
Probable DSBA oxidoreductase; COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis.
    
   0.594
ISM_15695
DSBA-like thioredoxin family protein; COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis.
    
   0.594
ISM_08180
Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1.
    
 
 0.538
tyrS
tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
       0.499
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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