| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_02140 | ISM_16420 | ISM_02140 | ISM_16420 | N-acetylmuramoyl-L-alanine amidase, family 2; COG3023 Negative regulator of beta-lactamase expression. | beta-N-acetylhexosaminidase, putative; COG1472 Beta-glucosidase-related glycosidases. | 0.543 |
| ISM_02140 | anmK | ISM_02140 | ISM_14645 | N-acetylmuramoyl-L-alanine amidase, family 2; COG3023 Negative regulator of beta-lactamase expression. | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.580 |
| ISM_05095 | ISM_15025 | ISM_05095 | ISM_15025 | Acyltransferase family protein; COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | 0.949 |
| ISM_05095 | anmK | ISM_05095 | ISM_14645 | Acyltransferase family protein; COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.447 |
| ISM_13030 | ISM_14205 | ISM_13030 | ISM_14205 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COG0546 Predicted phosphatases. | 0.589 |
| ISM_13030 | ISM_15025 | ISM_13030 | ISM_15025 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | 0.432 |
| ISM_13030 | ISM_16420 | ISM_13030 | ISM_16420 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | beta-N-acetylhexosaminidase, putative; COG1472 Beta-glucosidase-related glycosidases. | 0.500 |
| ISM_13030 | anmK | ISM_13030 | ISM_14645 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.494 |
| ISM_13030 | tyrS | ISM_13030 | ISM_14640 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. | 0.601 |
| ISM_14205 | ISM_13030 | ISM_14205 | ISM_13030 | COG0546 Predicted phosphatases. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.589 |
| ISM_14205 | anmK | ISM_14205 | ISM_14645 | COG0546 Predicted phosphatases. | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.495 |
| ISM_14650 | anmK | ISM_14650 | ISM_14645 | Asp/Glu/Hydantoin racemase family protein; COG3473 Maleate cis-trans isomerase. | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.780 |
| ISM_14650 | tyrS | ISM_14650 | ISM_14640 | Asp/Glu/Hydantoin racemase family protein; COG3473 Maleate cis-trans isomerase. | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. | 0.557 |
| ISM_15025 | ISM_05095 | ISM_15025 | ISM_05095 | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | Acyltransferase family protein; COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase. | 0.949 |
| ISM_15025 | ISM_13030 | ISM_15025 | ISM_13030 | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.432 |
| ISM_15025 | anmK | ISM_15025 | ISM_14645 | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.423 |
| ISM_16420 | ISM_02140 | ISM_16420 | ISM_02140 | beta-N-acetylhexosaminidase, putative; COG1472 Beta-glucosidase-related glycosidases. | N-acetylmuramoyl-L-alanine amidase, family 2; COG3023 Negative regulator of beta-lactamase expression. | 0.543 |
| ISM_16420 | ISM_13030 | ISM_16420 | ISM_13030 | beta-N-acetylhexosaminidase, putative; COG1472 Beta-glucosidase-related glycosidases. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.500 |
| ISM_16420 | anmK | ISM_16420 | ISM_14645 | beta-N-acetylhexosaminidase, putative; COG1472 Beta-glucosidase-related glycosidases. | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.604 |
| anmK | ISM_02140 | ISM_14645 | ISM_02140 | Hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | N-acetylmuramoyl-L-alanine amidase, family 2; COG3023 Negative regulator of beta-lactamase expression. | 0.580 |