| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_00020 | ISM_04875 | ISM_00020 | ISM_04875 | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.438 |
| ISM_00020 | ISM_04900 | ISM_00020 | ISM_04900 | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | 0.753 |
| ISM_00020 | ISM_04990 | ISM_00020 | ISM_04990 | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.676 |
| ISM_00020 | ISM_06020 | ISM_00020 | ISM_06020 | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.703 |
| ISM_00020 | ISM_06040 | ISM_00020 | ISM_06040 | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.770 |
| ISM_00020 | ISM_07715 | ISM_00020 | ISM_07715 | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | Formate dehydrogenase, alpha subunit; COG3383 Uncharacterized anaerobic dehydrogenase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.438 |
| ISM_00020 | ISM_09586 | ISM_00020 | ISM_09586 | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | Malate dehydrogenase; COG0281 Malic enzyme. | 0.778 |
| ISM_00020 | ISM_12240 | ISM_00020 | ISM_12240 | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | Hypothetical protein; COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.703 |
| ISM_00020 | ISM_14700 | ISM_00020 | ISM_14700 | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | 0.978 |
| ISM_00020 | nuoI | ISM_00020 | ISM_14365 | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | NADH dehydrogenase I, I subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. | 0.535 |
| ISM_04875 | ISM_00020 | ISM_04875 | ISM_00020 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | 0.438 |
| ISM_04875 | ISM_04900 | ISM_04875 | ISM_04900 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | 0.941 |
| ISM_04875 | ISM_06040 | ISM_04875 | ISM_06040 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Formate dehydrogenase, beta subunit; COG1905 NADH:ubiquinone oxidoreductase 24 kD subunit. | 0.996 |
| ISM_04875 | ISM_07715 | ISM_04875 | ISM_07715 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Formate dehydrogenase, alpha subunit; COG3383 Uncharacterized anaerobic dehydrogenase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.885 |
| ISM_04875 | ISM_09586 | ISM_04875 | ISM_09586 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | Malate dehydrogenase; COG0281 Malic enzyme. | 0.708 |
| ISM_04875 | ISM_14700 | ISM_04875 | ISM_14700 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | 0.964 |
| ISM_04875 | nuoI | ISM_04875 | ISM_14365 | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | NADH dehydrogenase I, I subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. | 0.913 |
| ISM_04900 | ISM_00020 | ISM_04900 | ISM_00020 | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | Iron-sulfur cluster-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. | 0.753 |
| ISM_04900 | ISM_04875 | ISM_04900 | ISM_04875 | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | Putative formate dehydrogenase large subunit; COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. | 0.941 |
| ISM_04900 | ISM_04990 | ISM_04900 | ISM_04990 | Iron-sulfur cluster-binding protein; COG1145 Ferredoxin. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.664 |