STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ISM_14825Lysine exporter family protein (LYSE/YGGA); COG1280 Putative threonine efflux protein. (203 aa)    
Predicted Functional Partners:
gpt
Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
  
    0.792
ISM_14830
COG0623 Enoyl-[acyl-carrier-protein] reductase (NADH).
       0.780
ISM_07530
Lysine exporter family protein (LYSE/YGGA); COG1280 Putative threonine efflux protein.
  
    0.779
ISM_01430
Transmembrane efflux protein, homoserine/threonine (RhtB) family protein; COG1280 Putative threonine efflux protein.
  
    0.769
ISM_14815
Aminotransferase, classes I and II; COG0436 Aspartate/tyrosine/aromatic aminotransferase.
       0.611
ISM_04410
Transporter, LysE family protein; COG1280 Putative threonine efflux protein.
  
    0.588
pdxH
Pyridoxamine 5''-phosphate oxidase, putative; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
       0.551
ISM_14810
Hypothetical protein; COG0760 Parvulin-like peptidyl-prolyl isomerase.
       0.471
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
       0.449
ISM_07525
Hypothetical protein; COG1280 Putative threonine efflux protein.
  
     0.410
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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