Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_15130Phosphatase, Ppx/GppA family protein; COG0248 Exopolyphosphatase. (329 aa)    
Predicted Functional Partners:
ISM_13785
guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
 
 
 0.910
ISM_00530
Phosphatase, Ppx/GppA family protein; COG0248 Exopolyphosphatase.
  
  
 
0.893
rlmE
Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
       0.845
ISM_15140
Phosphoglycerate mutase family protein; COG0406 Fructose-2,6-bisphosphatase.
       0.773
ppk
Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.
 
  
 0.621
ISM_15115
Hypothetical protein; COG1410 Methionine synthase I, cobalamin-binding domain.
  
  
 0.548
ISM_15125
Hypothetical protein.
       0.548
ISM_15120
metF-like protein; COG0685 5,10-methylenetetrahydrofolate reductase.
       0.521
ISM_13140
DNA-binding protein, putative; COG1396 Predicted transcriptional regulators.
   
    0.519
surE
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
 
   
 0.436
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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