| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_00280 | ISM_04775 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.805 |
| ISM_00280 | ISM_05545 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.836 |
| ISM_00280 | ISM_05685 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | Hypothetical protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. | 0.839 |
| ISM_00280 | ISM_05910 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.983 |
| ISM_00280 | ISM_06925 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.991 |
| ISM_00280 | ISM_07425 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | Putative two-component system sensor histidine kinase; COG2203 FOG: GAF domain. | 0.896 |
| ISM_00280 | ISM_15280 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | DNA-binding response regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. | 0.531 |
| ISM_00280 | ISM_15285 | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | COG4564 Signal transduction histidine kinase. | 0.627 |
| ISM_04775 | ISM_00280 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | 0.805 |
| ISM_04775 | ISM_05545 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.842 |
| ISM_04775 | ISM_05685 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Hypothetical protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. | 0.918 |
| ISM_04775 | ISM_05910 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.976 |
| ISM_04775 | ISM_06925 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.998 |
| ISM_04775 | ISM_07425 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | Putative two-component system sensor histidine kinase; COG2203 FOG: GAF domain. | 0.987 |
| ISM_04775 | ISM_15280 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | DNA-binding response regulator, LuxR family protein; COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain. | 0.679 |
| ISM_04775 | ISM_15285 | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | COG4564 Signal transduction histidine kinase. | 0.628 |
| ISM_05545 | ISM_00280 | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | Sensor histidine kinase of two-component; COG2202 FOG: PAS/PAC domain. | 0.836 |
| ISM_05545 | ISM_04775 | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.842 |
| ISM_05545 | ISM_05685 | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | Hypothetical protein; COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. | 0.930 |
| ISM_05545 | ISM_05910 | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.982 |