| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_06100 | ISM_15320 | ISM_06100 | ISM_15320 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0518 GMP synthase - Glutamine amidotransferase domain. | 0.567 |
| ISM_06100 | guaA | ISM_06100 | ISM_16255 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.871 |
| ISM_06100 | guaB | ISM_06100 | ISM_14860 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.953 |
| ISM_15320 | ISM_06100 | ISM_15320 | ISM_06100 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.567 |
| ISM_15320 | argS | ISM_15320 | ISM_16430 | COG0518 GMP synthase - Glutamine amidotransferase domain. | COG0018 Arginyl-tRNA synthetase. | 0.552 |
| ISM_15320 | gatA | ISM_15320 | ISM_02150 | COG0518 GMP synthase - Glutamine amidotransferase domain. | glutamyl-tRNA amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). | 0.551 |
| ISM_15320 | gatC | ISM_15320 | ISM_02155 | COG0518 GMP synthase - Glutamine amidotransferase domain. | glutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. | 0.554 |
| ISM_15320 | gmk | ISM_15320 | ISM_15575 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.790 |
| ISM_15320 | guaA | ISM_15320 | ISM_16255 | COG0518 GMP synthase - Glutamine amidotransferase domain. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.563 |
| ISM_15320 | guaB | ISM_15320 | ISM_14860 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.931 |
| ISM_15320 | map | ISM_15320 | ISM_00655 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.593 |
| ISM_15320 | rplK | ISM_15320 | ISM_01915 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.592 |
| ISM_15320 | surE | ISM_15320 | ISM_15875 | COG0518 GMP synthase - Glutamine amidotransferase domain. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.582 |
| argS | ISM_15320 | ISM_16430 | ISM_15320 | COG0018 Arginyl-tRNA synthetase. | COG0518 GMP synthase - Glutamine amidotransferase domain. | 0.552 |
| argS | gmk | ISM_16430 | ISM_15575 | COG0018 Arginyl-tRNA synthetase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.549 |
| argS | guaA | ISM_16430 | ISM_16255 | COG0018 Arginyl-tRNA synthetase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.963 |
| argS | map | ISM_16430 | ISM_00655 | COG0018 Arginyl-tRNA synthetase. | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.450 |
| argS | rplK | ISM_16430 | ISM_01915 | COG0018 Arginyl-tRNA synthetase. | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.646 |
| gatA | ISM_15320 | ISM_02150 | ISM_15320 | glutamyl-tRNA amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). | COG0518 GMP synthase - Glutamine amidotransferase domain. | 0.551 |
| gatA | gatC | ISM_02150 | ISM_02155 | glutamyl-tRNA amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). | glutamyl-tRNA(Gln) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. | 0.999 |