| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_02060 | ISM_03160 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | 0.910 |
| ISM_02060 | ISM_03165 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | 0.917 |
| ISM_02060 | ISM_04115 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | D-beta-hydroxybutyrate dehydrogenase, putative; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.605 |
| ISM_02060 | ISM_06100 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.451 |
| ISM_02060 | ISM_08180 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.772 |
| ISM_02060 | ISM_14265 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. | 0.596 |
| ISM_02060 | ISM_15675 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.608 |
| ISM_02660 | ISM_04115 | Ubiquinol--cytochrome c reductase, cytochrome B; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | D-beta-hydroxybutyrate dehydrogenase, putative; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.541 |
| ISM_02660 | ISM_08180 | Ubiquinol--cytochrome c reductase, cytochrome B; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.569 |
| ISM_02660 | ISM_15675 | Ubiquinol--cytochrome c reductase, cytochrome B; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. | COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.616 |
| ISM_03160 | ISM_02060 | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 0.910 |
| ISM_03160 | ISM_03165 | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | 0.999 |
| ISM_03160 | ISM_04115 | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | D-beta-hydroxybutyrate dehydrogenase, putative; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.742 |
| ISM_03160 | ISM_08180 | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | Vanillate O-demethylase oxidoreductase; COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.405 |
| ISM_03160 | ISM_14265 | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. | 0.914 |
| ISM_03160 | ISM_15675 | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). | 0.810 |
| ISM_03165 | ISM_02060 | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 0.917 |
| ISM_03165 | ISM_03160 | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | COG1788 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit. | 0.999 |
| ISM_03165 | ISM_04115 | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | D-beta-hydroxybutyrate dehydrogenase, putative; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.749 |
| ISM_03165 | ISM_14265 | COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit. | hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. | 0.903 |