Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_15730Hypothetical protein. (100 aa)    
Predicted Functional Partners:
ISM_15725
uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
 
  
 0.937
ISM_15745
COG3749 Uncharacterized protein conserved in bacteria.
 
    0.926
ISM_15740
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.904
ISM_15735
COG0155 Sulfite reductase, beta subunit (hemoprotein).
 
  
 0.894
ISM_15750
COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1.
       0.633
ISM_15720
Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators.
 
     0.594
ISM_11545
Hypothetical protein.
  
     0.554
ISM_09971
Rhomboid family protein; COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid).
  
     0.547
ISM_12660
uroporphyrin-III C-methyltransferase; COG0007 Uroporphyrinogen-III methylase.
 
  
 0.547
ISM_05920
Hypothetical protein; COG0419 ATPase involved in DNA repair.
  
     0.529
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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