| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_01450 | ISM_06020 | COG2086 Electron transfer flavoprotein, beta subunit. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.961 |
| ISM_01450 | ISM_12240 | COG2086 Electron transfer flavoprotein, beta subunit. | Hypothetical protein; COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.961 |
| ISM_01450 | ISM_12680 | COG2086 Electron transfer flavoprotein, beta subunit. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.961 |
| ISM_01450 | ISM_15750 | COG2086 Electron transfer flavoprotein, beta subunit. | COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.542 |
| ISM_06020 | ISM_01450 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | COG2086 Electron transfer flavoprotein, beta subunit. | 0.961 |
| ISM_06020 | ISM_08325 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.643 |
| ISM_06020 | ISM_12240 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | Hypothetical protein; COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.570 |
| ISM_06020 | ISM_12680 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.574 |
| ISM_06020 | ISM_15725 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.420 |
| ISM_06020 | ISM_15735 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | COG0155 Sulfite reductase, beta subunit (hemoprotein). | 0.521 |
| ISM_06020 | ISM_15740 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.493 |
| ISM_06020 | ISM_15750 | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.538 |
| ISM_08325 | ISM_06020 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.643 |
| ISM_08325 | ISM_12240 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Hypothetical protein; COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.643 |
| ISM_08325 | ISM_12680 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.643 |
| ISM_08325 | ISM_15750 | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1. | 0.579 |
| ISM_12240 | ISM_01450 | Hypothetical protein; COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | COG2086 Electron transfer flavoprotein, beta subunit. | 0.961 |
| ISM_12240 | ISM_06020 | Hypothetical protein; COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.570 |
| ISM_12240 | ISM_08325 | Hypothetical protein; COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | Bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.643 |
| ISM_12240 | ISM_12680 | Hypothetical protein; COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family. | 0.563 |
