STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa)    
Predicted Functional Partners:
ISM_01980
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
 
 
 0.984
pyrB
COG0540 Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
   
 
 0.984
ISM_13635
COG0167 Dihydroorotate dehydrogenase.
  
 
 0.954
ISM_09721
Dihydroorotase, multifunctional complex type; COG0044 Dihydroorotase and related cyclic amidohydrolases.
    
 0.926
carB
COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the CarB family.
   
 
 0.851
ISM_15780
Hypothetical protein.
       0.689
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.668
ISM_11810
HAD-superfamily subfamily IIA hydrolase; COG0647 Predicted sugar phosphatases of the HAD superfamily.
    
   0.629
carA
COG0505 Carbamoylphosphate synthase small subunit; Belongs to the CarA family.
   
  
 0.626
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
   
  
 0.569
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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