| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_00055 | ISM_16070 | ISM_00055 | ISM_16070 | COG1164 Oligoendopeptidase F. | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | 0.403 |
| ISM_02060 | ISM_16070 | ISM_02060 | ISM_16070 | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | 0.416 |
| ISM_16070 | ISM_00055 | ISM_16070 | ISM_00055 | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | COG1164 Oligoendopeptidase F. | 0.403 |
| ISM_16070 | ISM_02060 | ISM_16070 | ISM_02060 | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase /3-hydroxybutyryl-CoA epimerase; COG1024 Enoyl-CoA hydratase/carnithine racemase. | 0.416 |
| ISM_16070 | ISM_16080 | ISM_16070 | ISM_16080 | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | RNA methyltransferase, TrmH family, group 1; COG0565 rRNA methylase. | 0.720 |
| ISM_16070 | ISM_16085 | ISM_16070 | ISM_16085 | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | Putative thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. | 0.523 |
| ISM_16070 | ctaA | ISM_16070 | ISM_16075 | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | 0.861 |
| ISM_16070 | rho | ISM_16070 | ISM_06740 | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | 0.409 |
| ISM_16080 | ISM_16070 | ISM_16080 | ISM_16070 | RNA methyltransferase, TrmH family, group 1; COG0565 rRNA methylase. | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | 0.720 |
| ISM_16080 | ISM_16085 | ISM_16080 | ISM_16085 | RNA methyltransferase, TrmH family, group 1; COG0565 rRNA methylase. | Putative thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. | 0.654 |
| ISM_16080 | ctaA | ISM_16080 | ISM_16075 | RNA methyltransferase, TrmH family, group 1; COG0565 rRNA methylase. | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | 0.720 |
| ISM_16085 | ISM_16070 | ISM_16085 | ISM_16070 | Putative thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | 0.523 |
| ISM_16085 | ISM_16080 | ISM_16085 | ISM_16080 | Putative thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. | RNA methyltransferase, TrmH family, group 1; COG0565 rRNA methylase. | 0.654 |
| ISM_16085 | ctaA | ISM_16085 | ISM_16075 | Putative thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | 0.535 |
| ctaA | ISM_16070 | ISM_16075 | ISM_16070 | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | 0.861 |
| ctaA | ISM_16080 | ISM_16075 | ISM_16080 | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | RNA methyltransferase, TrmH family, group 1; COG0565 rRNA methylase. | 0.720 |
| ctaA | ISM_16085 | ISM_16075 | ISM_16085 | Cytochrome c oxidase assembly protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. | Putative thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. | 0.535 |
| rho | ISM_16070 | ISM_06740 | ISM_16070 | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. | 0.409 |