| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_01215 | ISM_03740 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.470 |
| ISM_01215 | ISM_03750 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.806 |
| ISM_01215 | ISM_04775 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.957 |
| ISM_01215 | ISM_05515 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.629 |
| ISM_01215 | ISM_05545 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.831 |
| ISM_01215 | ISM_05910 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.852 |
| ISM_01215 | ISM_06925 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.891 |
| ISM_01215 | ISM_16105 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Hypothetical protein. | 0.729 |
| ISM_03740 | ISM_01215 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.470 |
| ISM_03740 | ISM_03750 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.502 |
| ISM_03740 | ISM_04775 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.955 |
| ISM_03740 | ISM_05515 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.462 |
| ISM_03740 | ISM_05545 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Histidine kinase/response regulator hybrid protein; COG2202 FOG: PAS/PAC domain. | 0.831 |
| ISM_03740 | ISM_05910 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.830 |
| ISM_03740 | ISM_06925 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.873 |
| ISM_03740 | ISM_15085 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.450 |
| ISM_03740 | ISM_16105 | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Hypothetical protein. | 0.729 |
| ISM_03750 | ISM_01215 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.806 |
| ISM_03750 | ISM_03740 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two component diguanylate cyclase; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.502 |
| ISM_03750 | ISM_04775 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase. | 0.958 |