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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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ISM_16440Deoxyguanosinetriphosphate triphosphohydrolase, putative; COG0232 dGTP triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily. (388 aa)    
Predicted Functional Partners:
surE
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
 
  
  0.895
ISM_06870
HD domain protein; COG1896 Predicted hydrolases of HD superfamily.
  
 
  0.866
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 
  0.853
ISM_16435
Sodium/hydrogen exchanger; COG0025 NhaP-type Na+/H+ and K+/H+ antiporters.
       0.828
ISM_16445
Iron-sulfur cluster assembly family protein; Belongs to the HesB/IscA family.
     
 0.745
mtnP
5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
    
  0.744
ISM_10436
Sulfur oxidation B protein; COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family.
     
  0.739
argS
COG0018 Arginyl-tRNA synthetase.
  
    0.737
ribB
3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolaseII, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
    
  0.727
ISM_16420
beta-N-acetylhexosaminidase, putative; COG1472 Beta-glucosidase-related glycosidases.
       0.597
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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