Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ISM_16450Membrane protein, putative; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. (303 aa)    
Predicted Functional Partners:
ISM_16455
Hypothetical protein.
 
     0.941
ISM_16460
Hypothetical protein.
 
     0.871
ISM_15255
DNA-binding protein, putative; COG1396 Predicted transcriptional regulators.
  
     0.606
ISM_09190
COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily.
  
     0.590
ISM_15260
Hypothetical protein; COG3386 Gluconolactonase.
  
     0.495
ISM_03155
Membrane protein, putative; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily.
  
     0.486
ISM_09145
Membrane protein, putative; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily.
  
     0.477
ISM_11905
Membrane protein, putative; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily.
  
     0.426
secY
Preprotein translocase SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
   
   0.423
ISM_02955
Integral membrane protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily.
  
     0.406
Your Current Organism:
Roseovarius nubinhibens
NCBI taxonomy Id: 89187
Other names: R. nubinhibens ISM, Roseobacter sp. ISM, Roseovarius nubinhibens ISM, Roseovarius nubinhibens str. ISM, Roseovarius nubinhibens strain ISM, marine bacterium ISM
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