| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_02615 | ISM_06310 | ISM_02615 | ISM_06310 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 0.463 |
| ISM_02615 | ISM_08395 | ISM_02615 | ISM_08395 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | COG0837 Glucokinase; Belongs to the bacterial glucokinase family. | 0.427 |
| ISM_02615 | ISM_11610 | ISM_02615 | ISM_11610 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | 6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | 0.579 |
| ISM_02615 | ISM_13350 | ISM_02615 | ISM_13350 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | COG0021 Transketolase; Belongs to the transketolase family. | 0.962 |
| ISM_02615 | eno | ISM_02615 | ISM_16480 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.997 |
| ISM_02615 | mdh | ISM_02615 | ISM_05055 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.975 |
| ISM_02615 | pgi | ISM_02615 | ISM_16490 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | COG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family. | 0.984 |
| ISM_02615 | pgl | ISM_02615 | ISM_16495 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | 0.590 |
| ISM_02615 | tal | ISM_02615 | ISM_03480 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. | 0.870 |
| ISM_02615 | zwf | ISM_02615 | ISM_16500 | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.879 |
| ISM_06310 | ISM_02615 | ISM_06310 | ISM_02615 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.463 |
| ISM_06310 | ISM_11610 | ISM_06310 | ISM_11610 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. | 0.961 |
| ISM_06310 | ISM_13350 | ISM_06310 | ISM_13350 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | COG0021 Transketolase; Belongs to the transketolase family. | 0.985 |
| ISM_06310 | eno | ISM_06310 | ISM_16480 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.799 |
| ISM_06310 | mdh | ISM_06310 | ISM_05055 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.456 |
| ISM_06310 | pgi | ISM_06310 | ISM_16490 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | COG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family. | 0.719 |
| ISM_06310 | pgl | ISM_06310 | ISM_16495 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. | 0.533 |
| ISM_06310 | tal | ISM_06310 | ISM_03480 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. | 0.931 |
| ISM_06310 | zwf | ISM_06310 | ISM_16500 | COG0036 Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.861 |
| ISM_08395 | ISM_02615 | ISM_08395 | ISM_02615 | COG0837 Glucokinase; Belongs to the bacterial glucokinase family. | COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.427 |