| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_05405 | ISM_06100 | ISM_05405 | ISM_06100 | COG0174 Glutamine synthetase. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.933 |
| ISM_05405 | ISM_16535 | ISM_05405 | ISM_16535 | COG0174 Glutamine synthetase. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.536 |
| ISM_06100 | ISM_05405 | ISM_06100 | ISM_05405 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0174 Glutamine synthetase. | 0.933 |
| ISM_06100 | ISM_16535 | ISM_06100 | ISM_16535 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.433 |
| ISM_06100 | ISM_16640 | ISM_06100 | ISM_16640 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | 0.490 |
| ISM_06100 | glnD | ISM_06100 | ISM_09991 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.631 |
| ISM_06100 | nadE | ISM_06100 | ISM_02210 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.781 |
| ISM_10825 | ISM_16535 | ISM_10825 | ISM_16535 | AhpC/TSA family protein; COG1225 Peroxiredoxin. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.673 |
| ISM_16525 | ISM_16530 | ISM_16525 | ISM_16530 | Lipoprotein, putative. | Hypothetical protein. | 0.451 |
| ISM_16525 | ISM_16535 | ISM_16525 | ISM_16535 | Lipoprotein, putative. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.451 |
| ISM_16530 | ISM_16525 | ISM_16530 | ISM_16525 | Hypothetical protein. | Lipoprotein, putative. | 0.451 |
| ISM_16530 | ISM_16535 | ISM_16530 | ISM_16535 | Hypothetical protein. | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.853 |
| ISM_16530 | ISM_16540 | ISM_16530 | ISM_16540 | Hypothetical protein. | RDD family protein; COG1714 Predicted membrane protein/domain. | 0.633 |
| ISM_16530 | bpt | ISM_16530 | ISM_16545 | Hypothetical protein. | arginyl-tRNA-protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. Belongs to the R-transferase family. Bpt subfamily. | 0.421 |
| ISM_16535 | ISM_05405 | ISM_16535 | ISM_05405 | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | COG0174 Glutamine synthetase. | 0.536 |
| ISM_16535 | ISM_06100 | ISM_16535 | ISM_06100 | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.433 |
| ISM_16535 | ISM_10825 | ISM_16535 | ISM_10825 | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | AhpC/TSA family protein; COG1225 Peroxiredoxin. | 0.673 |
| ISM_16535 | ISM_16525 | ISM_16535 | ISM_16525 | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Lipoprotein, putative. | 0.451 |
| ISM_16535 | ISM_16530 | ISM_16535 | ISM_16530 | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Hypothetical protein. | 0.853 |
| ISM_16535 | ISM_16540 | ISM_16535 | ISM_16540 | Glutamate-ammonia ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | RDD family protein; COG1714 Predicted membrane protein/domain. | 0.643 |
