| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_09876 | ISM_09881 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.880 |
| ISM_09876 | ISM_15725 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.550 |
| ISM_09876 | ISM_16595 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | COG1522 Transcriptional regulators. | 0.768 |
| ISM_09881 | ISM_09876 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.880 |
| ISM_09881 | ISM_15725 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.550 |
| ISM_09881 | ISM_16595 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | COG1522 Transcriptional regulators. | 0.764 |
| ISM_13935 | ISM_15725 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.550 |
| ISM_13935 | ISM_16595 | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | COG1522 Transcriptional regulators. | 0.767 |
| ISM_15725 | ISM_09876 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.550 |
| ISM_15725 | ISM_09881 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.550 |
| ISM_15725 | ISM_13935 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.550 |
| ISM_15725 | ISM_16595 | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | COG1522 Transcriptional regulators. | 0.550 |
| ISM_16590 | ISM_16595 | COG0404 Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | COG1522 Transcriptional regulators. | 0.541 |
| ISM_16595 | ISM_09876 | COG1522 Transcriptional regulators. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.768 |
| ISM_16595 | ISM_09881 | COG1522 Transcriptional regulators. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.764 |
| ISM_16595 | ISM_13935 | COG1522 Transcriptional regulators. | Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. | 0.767 |
| ISM_16595 | ISM_15725 | COG1522 Transcriptional regulators. | uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.550 |
| ISM_16595 | ISM_16590 | COG1522 Transcriptional regulators. | COG0404 Glycine cleavage system T protein (aminomethyltransferase); Belongs to the GcvT family. | 0.541 |