| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_03750 | ISM_05515 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.518 |
| ISM_03750 | ISM_05910 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.913 |
| ISM_03750 | ISM_06925 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.937 |
| ISM_03750 | ISM_15085 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.520 |
| ISM_03750 | ISM_16630 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Nitrogen regulation protein ntrY; COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | 0.762 |
| ISM_03750 | ISM_16640 | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | 0.613 |
| ISM_05515 | ISM_03750 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.518 |
| ISM_05515 | ISM_05910 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.913 |
| ISM_05515 | ISM_06925 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.924 |
| ISM_05515 | ISM_16630 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Nitrogen regulation protein ntrY; COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | 0.779 |
| ISM_05515 | ISM_16640 | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | 0.506 |
| ISM_05910 | ISM_03750 | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | Sigma factor sigB regulation protein; COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.913 |
| ISM_05910 | ISM_05515 | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.913 |
| ISM_05910 | ISM_06925 | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | Sensor histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | 0.999 |
| ISM_05910 | ISM_07420 | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.913 |
| ISM_05910 | ISM_15085 | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.913 |
| ISM_05910 | ISM_16625 | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | Nitrogen assimilation regulatory protein NtrX; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.696 |
| ISM_05910 | ISM_16630 | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | Nitrogen regulation protein ntrY; COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. | 0.841 |
| ISM_05910 | ISM_16635 | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | Nitrogen regulation protein NtrC; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. | 0.696 |
| ISM_05910 | ISM_16640 | Sensory box histidine kinase/response regulator; COG0642 Signal transduction histidine kinase. | Nitrogen regulation protein NtrB; COG3852 Signal transduction histidine kinase, nitrogen specific. | 0.839 |