| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_08435 | ISM_09576 | ISM_08435 | ISM_09576 | COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. | propionate--CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | 0.643 |
| ISM_08435 | ISM_14240 | ISM_08435 | ISM_14240 | COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. | COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | 0.851 |
| ISM_08435 | ISM_14255 | ISM_08435 | ISM_14255 | COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. | COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. | 0.509 |
| ISM_08435 | ISM_16820 | ISM_08435 | ISM_16820 | COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. | COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. | 0.872 |
| ISM_08435 | ISM_16845 | ISM_08435 | ISM_16845 | COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. | COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). | 0.859 |
| ISM_08435 | ISM_17015 | ISM_08435 | ISM_17015 | COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. | COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. | 0.850 |
| ISM_08435 | acsA | ISM_08435 | ISM_01255 | COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.851 |
| ISM_09576 | ISM_08435 | ISM_09576 | ISM_08435 | propionate--CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. | 0.643 |
| ISM_09576 | ISM_14240 | ISM_09576 | ISM_14240 | propionate--CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | 0.880 |
| ISM_09576 | ISM_14255 | ISM_09576 | ISM_14255 | propionate--CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. | 0.466 |
| ISM_09576 | ISM_16740 | ISM_09576 | ISM_16740 | propionate--CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.736 |
| ISM_09576 | ISM_16820 | ISM_09576 | ISM_16820 | propionate--CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. | 0.861 |
| ISM_09576 | ISM_16845 | ISM_09576 | ISM_16845 | propionate--CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). | 0.867 |
| ISM_09576 | ISM_17015 | ISM_09576 | ISM_17015 | propionate--CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. | 0.643 |
| ISM_09576 | acsA | ISM_09576 | ISM_01255 | propionate--CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.850 |
| ISM_11525 | ISM_14255 | ISM_11525 | ISM_14255 | methylmalonyl-CoA epimerase; COG0346 Lactoylglutathione lyase and related lyases. | COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. | 0.778 |
| ISM_11525 | ISM_16740 | ISM_11525 | ISM_16740 | methylmalonyl-CoA epimerase; COG0346 Lactoylglutathione lyase and related lyases. | Non-ribosomal peptide synthase; COG3321 Polyketide synthase modules and related proteins. | 0.915 |
| ISM_11525 | ISM_16800 | ISM_11525 | ISM_16800 | methylmalonyl-CoA epimerase; COG0346 Lactoylglutathione lyase and related lyases. | COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit. | 0.983 |
| ISM_11525 | ISM_16820 | ISM_11525 | ISM_16820 | methylmalonyl-CoA epimerase; COG0346 Lactoylglutathione lyase and related lyases. | COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit. | 0.923 |
| ISM_11525 | ISM_16845 | ISM_11525 | ISM_16845 | methylmalonyl-CoA epimerase; COG0346 Lactoylglutathione lyase and related lyases. | COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta). | 0.983 |