| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISM_03095 | ISM_14415 | ISM_03095 | ISM_14415 | COG0498 Threonine synthase. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.498 |
| ISM_03095 | ISM_15265 | ISM_03095 | ISM_15265 | COG0498 Threonine synthase. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.748 |
| ISM_03095 | ISM_17160 | ISM_03095 | ISM_17160 | COG0498 Threonine synthase. | Diaminopropionate ammonia-lyase; COG1171 Threonine dehydratase. | 0.707 |
| ISM_03095 | ilvD | ISM_03095 | ISM_08925 | COG0498 Threonine synthase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.490 |
| ISM_03095 | leuB | ISM_03095 | ISM_10241 | COG0498 Threonine synthase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.659 |
| ISM_10521 | ISM_17160 | ISM_10521 | ISM_17160 | COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. | Diaminopropionate ammonia-lyase; COG1171 Threonine dehydratase. | 0.798 |
| ISM_14415 | ISM_03095 | ISM_14415 | ISM_03095 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0498 Threonine synthase. | 0.498 |
| ISM_14415 | ISM_14700 | ISM_14415 | ISM_14700 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | 0.606 |
| ISM_14415 | ISM_15265 | ISM_14415 | ISM_15265 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.618 |
| ISM_14415 | ISM_17160 | ISM_14415 | ISM_17160 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Diaminopropionate ammonia-lyase; COG1171 Threonine dehydratase. | 0.590 |
| ISM_14415 | ilvD | ISM_14415 | ISM_08925 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.957 |
| ISM_14650 | ISM_17155 | ISM_14650 | ISM_17155 | Asp/Glu/Hydantoin racemase family protein; COG3473 Maleate cis-trans isomerase. | Metallopeptidase, family M24; COG0006 Xaa-Pro aminopeptidase. | 0.770 |
| ISM_14650 | ISM_17160 | ISM_14650 | ISM_17160 | Asp/Glu/Hydantoin racemase family protein; COG3473 Maleate cis-trans isomerase. | Diaminopropionate ammonia-lyase; COG1171 Threonine dehydratase. | 0.679 |
| ISM_14700 | ISM_14415 | ISM_14700 | ISM_14415 | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.606 |
| ISM_14700 | ISM_15265 | ISM_14700 | ISM_15265 | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.751 |
| ISM_14700 | ISM_17160 | ISM_14700 | ISM_17160 | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | Diaminopropionate ammonia-lyase; COG1171 Threonine dehydratase. | 0.610 |
| ISM_14700 | leuB | ISM_14700 | ISM_10241 | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.753 |
| ISM_14700 | trpB | ISM_14700 | ISM_13910 | COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits. | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.412 |
| ISM_15265 | ISM_03095 | ISM_15265 | ISM_03095 | COG0440 Acetolactate synthase, small (regulatory) subunit. | COG0498 Threonine synthase. | 0.748 |
| ISM_15265 | ISM_14415 | ISM_15265 | ISM_14415 | COG0440 Acetolactate synthase, small (regulatory) subunit. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.618 |