| node1 | node2 | node1 annotation | node2 annotation | score |
| ISM_17330 | ISM_17340 | Hypothetical protein; COG3704 Type IV secretory pathway, VirB6 components. | Type IV secretion system protein B11, putative; COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis. | 0.786 |
| ISM_17330 | ISM_17345 | Hypothetical protein; COG3704 Type IV secretory pathway, VirB6 components. | Conjugal transfer protein; COG2948 Type IV secretory pathway, VirB10 components. | 0.984 |
| ISM_17330 | ISM_17350 | Hypothetical protein; COG3704 Type IV secretory pathway, VirB6 components. | Conjugal transfer protein, trbG; COG3504 Type IV secretory pathway, VirB9 components. | 0.989 |
| ISM_17330 | ISM_17355 | Hypothetical protein; COG3704 Type IV secretory pathway, VirB6 components. | COG3736 Type IV secretory pathway, component VirB8. | 0.979 |
| ISM_17330 | ISM_17360 | Hypothetical protein; COG3704 Type IV secretory pathway, VirB6 components. | TraF protein; COG0840 Methyl-accepting chemotaxis protein. | 0.852 |
| ISM_17330 | ISM_17365 | Hypothetical protein; COG3704 Type IV secretory pathway, VirB6 components. | Hypothetical protein; COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). | 0.791 |
| ISM_17330 | ISM_17375 | Hypothetical protein; COG3704 Type IV secretory pathway, VirB6 components. | Type IV secretion system protein B4, putative; COG3451 Type IV secretory pathway, VirB4 components. | 0.984 |
| ISM_17330 | ISM_17380 | Hypothetical protein; COG3704 Type IV secretory pathway, VirB6 components. | COG3702 Type IV secretory pathway, VirB3 components. | 0.976 |
| ISM_17330 | ISM_17385 | Hypothetical protein; COG3704 Type IV secretory pathway, VirB6 components. | Hypothetical protein; COG0025 NhaP-type Na+/H+ and K+/H+ antiporters. | 0.848 |
| ISM_17330 | ISM_17825 | Hypothetical protein; COG3704 Type IV secretory pathway, VirB6 components. | Type IV secretion system coupling protein; COG3505 Type IV secretory pathway, VirD4 components. | 0.803 |
| ISM_17340 | ISM_17330 | Type IV secretion system protein B11, putative; COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis. | Hypothetical protein; COG3704 Type IV secretory pathway, VirB6 components. | 0.786 |
| ISM_17340 | ISM_17345 | Type IV secretion system protein B11, putative; COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis. | Conjugal transfer protein; COG2948 Type IV secretory pathway, VirB10 components. | 0.983 |
| ISM_17340 | ISM_17350 | Type IV secretion system protein B11, putative; COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis. | Conjugal transfer protein, trbG; COG3504 Type IV secretory pathway, VirB9 components. | 0.984 |
| ISM_17340 | ISM_17355 | Type IV secretion system protein B11, putative; COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis. | COG3736 Type IV secretory pathway, component VirB8. | 0.948 |
| ISM_17340 | ISM_17360 | Type IV secretion system protein B11, putative; COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis. | TraF protein; COG0840 Methyl-accepting chemotaxis protein. | 0.939 |
| ISM_17340 | ISM_17365 | Type IV secretion system protein B11, putative; COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis. | Hypothetical protein; COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains). | 0.945 |
| ISM_17340 | ISM_17375 | Type IV secretion system protein B11, putative; COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis. | Type IV secretion system protein B4, putative; COG3451 Type IV secretory pathway, VirB4 components. | 0.970 |
| ISM_17340 | ISM_17380 | Type IV secretion system protein B11, putative; COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis. | COG3702 Type IV secretory pathway, VirB3 components. | 0.905 |
| ISM_17340 | ISM_17385 | Type IV secretion system protein B11, putative; COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis. | Hypothetical protein; COG0025 NhaP-type Na+/H+ and K+/H+ antiporters. | 0.939 |
| ISM_17340 | ISM_17825 | Type IV secretion system protein B11, putative; COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis. | Type IV secretion system coupling protein; COG3505 Type IV secretory pathway, VirD4 components. | 0.787 |