POU2F3 protein (Columba livia) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

POU2F3

POU domain protein. (532 aa)

Predicted Functional Partners:

SP1

0.658

POU2AF1

0.637

SNAPC4

0.631

PLA1A

0.595

GTF2B

0.586

SNAPC3

0.581

SNAPC1

0.579

GTF2A1

0.577

PCF11

0.563

GTF2F1

0.559

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GTF2A1	GTF2B	A0A2I0MNB0	A0A2I0MDZ9	General transcription factor IIA, 1, 19/37kDa.	General transcription factor IIB.	0.982
GTF2A1	GTF2F1	A0A2I0MNB0	A0A2I0LH97	General transcription factor IIA, 1, 19/37kDa.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.935
GTF2A1	POU2F3	A0A2I0MNB0	A0A2I0LQX0	General transcription factor IIA, 1, 19/37kDa.	POU domain protein.	0.577
GTF2A1	SNAPC1	A0A2I0MNB0	A0A2I0MPK6	General transcription factor IIA, 1, 19/37kDa.	Small nuclear RNA activating complex, polypeptide 1, 43kDa.	0.826
GTF2A1	SNAPC3	A0A2I0MNB0	A0A2I0MFR5	General transcription factor IIA, 1, 19/37kDa.	Small nuclear RNA activating complex, polypeptide 3, 50kDa, transcript variant X1.	0.861
GTF2A1	SNAPC4	A0A2I0MNB0	A0A2I0M3Y7	General transcription factor IIA, 1, 19/37kDa.	Small nuclear RNA activating complex, polypeptide 4, 190kDa.	0.915
GTF2A1	SP1	A0A2I0MNB0	A0A2I0LKC0	General transcription factor IIA, 1, 19/37kDa.	Sp1 transcription factor.	0.626
GTF2B	GTF2A1	A0A2I0MDZ9	A0A2I0MNB0	General transcription factor IIB.	General transcription factor IIA, 1, 19/37kDa.	0.982
GTF2B	GTF2F1	A0A2I0MDZ9	A0A2I0LH97	General transcription factor IIB.	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	0.994
GTF2B	PCF11	A0A2I0MDZ9	A0A2I0M103	General transcription factor IIB.	PCF11 cleavage and polyadenylation factor subunit.	0.812
GTF2B	POU2F3	A0A2I0MDZ9	A0A2I0LQX0	General transcription factor IIB.	POU domain protein.	0.586
GTF2B	SNAPC1	A0A2I0MDZ9	A0A2I0MPK6	General transcription factor IIB.	Small nuclear RNA activating complex, polypeptide 1, 43kDa.	0.919
GTF2B	SNAPC3	A0A2I0MDZ9	A0A2I0MFR5	General transcription factor IIB.	Small nuclear RNA activating complex, polypeptide 3, 50kDa, transcript variant X1.	0.870
GTF2B	SNAPC4	A0A2I0MDZ9	A0A2I0M3Y7	General transcription factor IIB.	Small nuclear RNA activating complex, polypeptide 4, 190kDa.	0.828
GTF2B	SP1	A0A2I0MDZ9	A0A2I0LKC0	General transcription factor IIB.	Sp1 transcription factor.	0.634
GTF2F1	GTF2A1	A0A2I0LH97	A0A2I0MNB0	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	General transcription factor IIA, 1, 19/37kDa.	0.935
GTF2F1	GTF2B	A0A2I0LH97	A0A2I0MDZ9	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	General transcription factor IIB.	0.994
GTF2F1	PCF11	A0A2I0LH97	A0A2I0M103	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	PCF11 cleavage and polyadenylation factor subunit.	0.632
GTF2F1	POU2F3	A0A2I0LH97	A0A2I0LQX0	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	POU domain protein.	0.559
GTF2F1	SNAPC3	A0A2I0LH97	A0A2I0MFR5	Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.	Small nuclear RNA activating complex, polypeptide 3, 50kDa, transcript variant X1.	0.827

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Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.816

expected number of edges:

10

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2001240

Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

3 of 21

2.78

2.06

0.00017

GO:0039528

Cytoplasmic pattern recognition receptor signaling pathway in response to virus

2 of 14

2.78

1.09

0.0107

GO:0038061

NIK/NF-kappaB signaling

2 of 30

2.45

0.82

0.0316

GO:0061709

Reticulophagy

2 of 38

2.35

0.81

0.0336

GO:0002218

Activation of innate immune response

2 of 36

2.37

0.81

0.0336

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035438

cyclic-di-GMP binding

2 of 2

3.63

1.68

0.00095

GO:0061507

2,3-cyclic GMP-AMP binding

2 of 4

3.32

1.62

0.0012

GO:0015459

Potassium channel regulator activity

3 of 98

2.11

1.44

0.0017

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005793

Endoplasmic reticulum-Golgi intermediate compartment

4 of 144

2.07

2.18

4.23e-05

GO:0055037

Recycling endosome

3 of 298

1.63

0.98

0.0094

GO:0033116

Endoplasmic reticulum-Golgi intermediate compartment membrane

2 of 70

2.08

0.89

0.0217

GO:0000421

Autophagosome membrane

2 of 66

2.11

0.89

0.0217

GO:0030134

COPII-coated ER to Golgi transport vesicle

2 of 117

1.86

0.7

0.0465

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7052

Mixed, incl. PDPK1 family, and CISK, PX domain

4 of 10

3.23

4.29

1.56e-08

CL:28606

Mixed, incl. Fork head domain conserved site1, and Interferon regulatory factor

3 of 89

2.15

1.49

0.0014

CL:28620

Mixed, incl. cyclic-di-GMP binding, and Regulation of MyD88-dependent toll-like receptor signaling pathway

2 of 11

2.89

1.37

0.0033

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04068

FoxO signaling pathway

4 of 477

1.55

1.36

0.00070

map04623

Cytosolic DNA-sensing pathway

2 of 96

1.94

0.85

0.0238

map04621

NOD-like receptor signaling pathway

3 of 745

1.23

0.61

0.0413

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3270619

IRF3-mediated induction of type I IFN

2 of 8

3.02

1.41

0.0028

MAP-3249367

STAT6-mediated induction of chemokines

2 of 12

2.85

1.41

0.0028

MAP-3134975

Regulation of innate immune responses to cytosolic DNA

2 of 17

2.7

1.34

0.0037

MAP-1834941

STING mediated induction of host immune responses

2 of 19

2.65

1.33

0.0037

MAP-2672351

Stimuli-sensing channels

4 of 394

1.63

1.19

0.0028

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF15009

Transmembrane protein 173

2 of 2

3.63

1.65

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047191

Stimulator of interferon genes protein, C-terminal

2 of 2

3.63

1.4

0.0031

IPR038623

Stimulator of interferon genes protein, C-terminal domain superfamily

2 of 2

3.63

1.4

0.0031

IPR037900

CISK, PX domain

2 of 2

3.63

1.4

0.0031

IPR029158

Stimulator of interferon genes protein

2 of 2

3.63

1.4

0.0031

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