FYB protein (Columba livia) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

FYB

FYN binding protein. (503 aa)

Predicted Functional Partners:

ITSN2

0.949

LCP2

0.836

ITSN1

0.747

MYO6

0.701

RELN

0.635

SKAP2

0.635

SKAP1

0.629

GRAP2

0.621

SPIRE2

0.543

A306_00002940

0.543

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00002940	FYB	A0A2I0MRP3	A0A2I0LTV1	Protein spire homolog 1.	FYN binding protein.	0.543
A306_00002940	GRAP2	A0A2I0MRP3	A0A2I0MJS2	Protein spire homolog 1.	GRB2-related adaptor protein 2, transcript variant X1.	0.826
FYB	A306_00002940	A0A2I0LTV1	A0A2I0MRP3	FYN binding protein.	Protein spire homolog 1.	0.543
FYB	GRAP2	A0A2I0LTV1	A0A2I0MJS2	FYN binding protein.	GRB2-related adaptor protein 2, transcript variant X1.	0.621
FYB	ITSN1	A0A2I0LTV1	A0A2I0MTB3	FYN binding protein.	Intersectin 1 (SH3 domain protein).	0.747
FYB	ITSN2	A0A2I0LTV1	A0A2I0MVD2	FYN binding protein.	Intersectin 2.	0.949
FYB	LCP2	A0A2I0LTV1	A0A2I0M9Z1	FYN binding protein.	Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa).	0.836
FYB	MYO6	A0A2I0LTV1	A0A2I0MTQ0	FYN binding protein.	Myosin VI, transcript variant X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.701
FYB	RELN	A0A2I0LTV1	A0A2I0MHD6	FYN binding protein.	Reelin.	0.635
FYB	SKAP1	A0A2I0LTV1	A0A2I0LSC1	FYN binding protein.	Src kinase associated phosphoprotein 1.	0.629
FYB	SKAP2	A0A2I0LTV1	A0A2I0MQ53	FYN binding protein.	Src kinase associated phosphoprotein 2.	0.635
FYB	SPIRE2	A0A2I0LTV1	A0A2I0LJ38	FYN binding protein.	Spire-type actin nucleation factor 2.	0.543
GRAP2	A306_00002940	A0A2I0MJS2	A0A2I0MRP3	GRB2-related adaptor protein 2, transcript variant X1.	Protein spire homolog 1.	0.826
GRAP2	FYB	A0A2I0MJS2	A0A2I0LTV1	GRB2-related adaptor protein 2, transcript variant X1.	FYN binding protein.	0.621
GRAP2	ITSN1	A0A2I0MJS2	A0A2I0MTB3	GRB2-related adaptor protein 2, transcript variant X1.	Intersectin 1 (SH3 domain protein).	0.644
GRAP2	ITSN2	A0A2I0MJS2	A0A2I0MVD2	GRB2-related adaptor protein 2, transcript variant X1.	Intersectin 2.	0.921
GRAP2	LCP2	A0A2I0MJS2	A0A2I0M9Z1	GRB2-related adaptor protein 2, transcript variant X1.	Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa).	0.987
GRAP2	SPIRE2	A0A2I0MJS2	A0A2I0LJ38	GRB2-related adaptor protein 2, transcript variant X1.	Spire-type actin nucleation factor 2.	0.826
ITSN1	FYB	A0A2I0MTB3	A0A2I0LTV1	Intersectin 1 (SH3 domain protein).	FYN binding protein.	0.747
ITSN1	GRAP2	A0A2I0MTB3	A0A2I0MJS2	Intersectin 1 (SH3 domain protein).	GRB2-related adaptor protein 2, transcript variant X1.	0.644

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.879

expected number of edges:

42

PPI enrichment p-value:

0.995

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

5 of 22

1.87

2.29

9.82e-06

GO:0009408

Response to heat

3 of 10

1.99

1.23

0.0041

GO:0051603

Proteolysis involved in protein catabolic process

2 of 4

2.21

0.79

0.0344

GO:0050821

Protein stabilization

2 of 4

2.21

0.79

0.0344

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005515

Protein binding

6 of 48

1.61

2.14

2.81e-06

GO:0051082

Unfolded protein binding

3 of 10

1.99

1.36

0.0022

GO:0140662

ATP-dependent protein folding chaperone

2 of 4

2.21

0.88

0.0237

GO:0004176

ATP-dependent peptidase activity

2 of 4

2.21

0.88

0.0237

GO:0140657

ATP-dependent activity

5 of 137

1.08

0.74

0.0085

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1235

0.46

0.38

0.0011

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36350115

(2022) Shared properties of gene transfer agent and core genes revealed by comparative genomics of Alphaproteobacteria.

2 of 3

2.34

1.12

0.0086

PMID:32093084

(2020) Adaptation to Photooxidative Stress: Common and Special Strategies of the Alphaproteobacteria Rhodobacter sphaeroides and Rhodobacter capsulatus.

3 of 26

1.58

0.98

0.0086

PMID:33780465

(2021) Adaptation of Dinoroseobacter shibae to oxidative stress and the specific role of RirA.

3 of 51

1.28

0.75

0.0186

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:378

Chaperone, and Cellular response to heat

10 of 16

2.31

7.89

5.09e-19

CL:381

Stress response, and Protein folding chaperone

8 of 10

2.42

6.85

2.99e-15

CL:384

Protein folding chaperone, and Chaperone binding

4 of 5

2.42

3.15

8.49e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236975

Antigen processing-Cross presentation

3 of 4

2.39

2.58

1.19e-05

MAP-983169

Class I MHC mediated antigen processing & presentation

3 of 6

2.21

2.47

1.42e-05

MAP-1280218

Adaptive Immune System

3 of 6

2.21

2.47

1.42e-05

MAP-168256

Immune System

3 of 27

1.56

1.48

0.00033

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009368

Endopeptidase Clp complex

2 of 3

2.34

0.86

0.0262

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

8 of 16

2.21

5.89

3.95e-14

KW-0143

Chaperone

5 of 23

1.85

2.62

9.96e-07

KW-0720

Serine protease

2 of 5

2.12

1.09

0.0088

KW-0645

Protease

3 of 34

1.46

0.93

0.0088

KW-0963

Cytoplasm

7 of 252

0.96

0.89

0.00018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00011

Hsp20/alpha crystallin family

3 of 3

2.51

1.95

0.00024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008978

HSP20-like chaperone

3 of 3

2.51

1.73

0.00064

IPR002068

Alpha crystallin/Hsp20 domain

3 of 3

2.51

1.73

0.00064

IPR037913

Small heat shock protein IbpA/IbpB, ACD domain

2 of 2

2.51

0.88

0.0255

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