A306_00011325 protein (Columba livia) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Cooccurrence

Coexpression

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[Homology]

Score

A306_00011325

Carboxypeptidase A1. (466 aa)

Predicted Functional Partners:

A306_00013934

0.454

A306_00012920

0.454

CTRC

0.454

A306_00006159

0.454

CPN1

0.408

Your Current Organism:

Columba livia

NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A306_00006159	A306_00011325	A0A2I0M3B0	A0A2I0LXA5	Chymotrypsin-like elastase family member 2A; Belongs to the peptidase S1 family.	Carboxypeptidase A1.	0.454
A306_00011325	A306_00006159	A0A2I0LXA5	A0A2I0M3B0	Carboxypeptidase A1.	Chymotrypsin-like elastase family member 2A; Belongs to the peptidase S1 family.	0.454
A306_00011325	A306_00012920	A0A2I0LXA5	A0A2I0LMH4	Carboxypeptidase A1.	Chymotrypsin-like elastase family member 1.	0.454
A306_00011325	A306_00013934	A0A2I0LXA5	A0A2I0LLM2	Carboxypeptidase A1.	Proproteinase E; Belongs to the peptidase S1 family.	0.454
A306_00011325	CPN1	A0A2I0LXA5	A0A2I0LV14	Carboxypeptidase A1.	Carboxypeptidase N, polypeptide 1.	0.408
A306_00011325	CTRC	A0A2I0LXA5	A0A2I0M384	Carboxypeptidase A1.	Chymotrypsin C (Caldecrin); Belongs to the peptidase S1 family.	0.454
A306_00012920	A306_00011325	A0A2I0LMH4	A0A2I0LXA5	Chymotrypsin-like elastase family member 1.	Carboxypeptidase A1.	0.454
A306_00013934	A306_00011325	A0A2I0LLM2	A0A2I0LXA5	Proproteinase E; Belongs to the peptidase S1 family.	Carboxypeptidase A1.	0.454
CPN1	A306_00011325	A0A2I0LV14	A0A2I0LXA5	Carboxypeptidase N, polypeptide 1.	Carboxypeptidase A1.	0.408
CTRC	A306_00011325	A0A2I0M384	A0A2I0LXA5	Chymotrypsin C (Caldecrin); Belongs to the peptidase S1 family.	Carboxypeptidase A1.	0.454

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

6.25e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009132

Nucleoside diphosphate metabolic process

7 of 58

2.45

6.02

4.55e-13

GO:0072528

Pyrimidine-containing compound biosynthetic process

5 of 28

2.62

4.81

5.53e-10

GO:0009142

Nucleoside triphosphate biosynthetic process

5 of 29

2.6

4.78

6.02e-10

GO:0009141

Nucleoside triphosphate metabolic process

6 of 73

2.28

4.67

1.67e-10

GO:0090407

Organophosphate biosynthetic process

9 of 281

1.87

4.45

4.55e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

6 of 25

2.74

6.13

1.82e-12

GO:0019205

Nucleobase-containing compound kinase activity

6 of 29

2.68

6.04

2.01e-12

GO:0004550

Nucleoside diphosphate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0004017

Adenylate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 765

1.32

1.68

2.39e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36277867

(2022) Cold-induced denaturation of muscle proteins in hairtail (Trichiurus lepturus) during storage: Physicochemical and label-free based proteomics analyses.

3 of 52

2.12

1.26

0.0040

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5678

Purine metabolism

9 of 40

2.72

9.69

3.16e-20

CL:5732

Mixed, incl. CTP metabolic process, and Adenylate kinase activity

7 of 13

3.09

9.1

9.18e-18

CL:5673

Mixed, incl. Purine metabolism, and Metabolism of nucleotides

10 of 157

2.17

7.13

1.42e-18

CL:5748

Adenylate kinase activity, and ATP cone domain

4 of 5

3.27

4.99

8.16e-10

CL:5734

Nucleoside diphosphate kinase, and Purine ribonucleoside bisphosphate metabolic process

2 of 5

2.97

1.63

0.0011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pvm00230

Purine metabolism

9 of 76

2.44

8.5

2.35e-19

pvm00730

Thiamine metabolism

5 of 10

3.06

6.48

9.96e-13

pvm00240

Pyrimidine metabolism

5 of 36

2.51

5.02

1.24e-10

pvm00983

Drug metabolism - other enzymes

4 of 49

2.28

3.42

1.40e-07

pvm01100

Metabolic pathways

10 of 991

1.37

2.44

3.87e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-499943

Interconversion of nucleotide di- and triphosphates

5 of 21

2.74

4.93

4.73e-10

MAP-15869

Metabolism of nucleotides

6 of 104

2.12

4.02

1.80e-09

MAP-1430728

Metabolism

7 of 2301

0.85

0.61

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

7 of 411

1.59

2.59

2.75e-08

KW-0547

Nucleotide-binding

6 of 685

1.31

1.48

2.31e-05

KW-0067

ATP-binding

5 of 552

1.32

1.33

0.00015

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13207

AAA domain

3 of 5

3.14

2.93

4.83e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034907

Nucleoside diphosphate kinase-like domain

3 of 3

3.36

2.93

5.10e-06

IPR001564

Nucleoside diphosphate kinase

3 of 3

3.36

2.93

5.10e-06

IPR036850

Nucleoside diphosphate kinase-like domain superfamily

3 of 5

3.14

2.92

5.10e-06

IPR033690

Adenylate kinase, conserved site

3 of 5

3.14

2.92

5.10e-06

IPR000850

Adenylate kinase/UMP-CMP kinase

3 of 6

3.06

2.91

5.10e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00562

These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.

3 of 3

3.36

3.43

6.44e-07

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