STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TOPORSTopoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase. (997 aa)    
Predicted Functional Partners:
UBE2I
Ubiquitin-conjugating enzyme E2I; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.799
SUMO1
Small ubiquitin-related modifier.
    
 0.748
TOP1
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.573
SENP7
SUMO1/sentrin specific peptidase 7, transcript variant X2.
   
  
 0.560
A306_00010235
Small ubiquitin-related modifier 3.
    
 0.553
SUMO2
Small ubiquitin-related modifier.
    
 0.553
MLXIPL
MLX interacting protein-like.
      
 0.546
MTAP
Methylthioadenosine phosphorylase.
 
    
 0.546
KIF3A
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
      
 0.542
TRIP12
Thyroid hormone receptor interactor 12, transcript variant X1.
      
 0.536
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.