STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KPNA2Karyopherin alpha 2 (RAG cohort 1, importin alpha 1). (440 aa)    
Predicted Functional Partners:
KPNB1
Karyopherin (Importin) beta 1, transcript variant X2.
   
 0.865
RANBP1
RAN binding protein 1.
   
 
 0.724
NCBP1
Nuclear cap binding protein subunit 1, 80kDa.
   
 
 0.715
RANBP2
RAN binding protein 2, transcript variant X1.
   
 
 0.708
CSE1L
Importin N-terminal domain-containing protein.
   
 
 0.699
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 
 0.658
CDK1
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
 
 
 0.651
NUP50
Nucleoporin 50kDa, transcript variant X1.
   
 
 0.650
RCC1
Regulator of chromosome condensation 1.
   
 
 0.627
CCNB2
Cyclin B2; Belongs to the cyclin family.
   
 
 0.601
Your Current Organism:
Columba livia
NCBI taxonomy Id: 8932
Other names: C. livia, Columba domestica, Columba livia domestica, carrier pigeon, domestic pigeon, rock dove, rock pigeon
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.